Results 41 to 50 of about 7,382,518 (304)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Klinik Psikiyatri Dergisi, 2022 INTRODUCTION: It was aimed to investigate the relationship between remission time and quality of life, functionality and craving in patients with opiate use disorder (OUD).
Mehmet Murat Balcı +3 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Exploring the business dynamics of self-employed child care service providers
Economic and Social Reports, 2022 Child care in Canada is essential for supporting paid employment for parents, particularly women who do the majority of child care work. This paper examines the characteristics and evolution of the population of small home daycares and their operators ...
Chahreddine Abbes, Ryan Macdonald
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Bangladesh Journal of Bioethics, 2023 CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) as a gene editing tool is a precise and promising technology. By CRISPR technology, human gene can be introduced into the animal gene pool to develop chimera for human like cells/tissue.
Arif Jamil +3 more
doaj +1 more source
The Employees of Native and Immigrant Self-Employed [PDF]
SSRN Electronic Journal, 2007 Using unique register data for Sweden we can match self-employed persons to their employees. We analyze the national composition of the employees and ask if self-employed immigrants mainly employ workers from their home region and if self-employed natives mainly employ native workers.
Andersson, Pernilla, Wadensjö, Eskil
openaire +2 more sources
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Poultry Science: A brood of laying hens infested with the lice Menacanthus cornutus (Phthiraptera: Menoponidae) evidenced itching, irritation, and damage to their zootechnical performance.
Gustavo Perdoncini +6 more
doaj +1 more source
Qualitative evaluation of the new rapid point-of-care antigen Afias Covid-19/Flu Ag Combo assay
Microbiologia Medica, 2021 Background: An interim guidance document by the WHO (World Health Organization) suggests the use of rapid diagnostic tests based on antigen detection as an alternative to the real-time PCR test for the diagnosis of SARS-CoV2 infection, when the molecular
Mara Lorusso +5 more
doaj +1 more source