Results 91 to 100 of about 330,215 (300)

Improving communication and practical skills in working with inpatients who self-harm: a pre-test/post-test study of the effects of a training programme [PDF]

, 2014
BACKGROUND: Differing perspectives of self-harm may result in a struggle between patients and treatment staff. As a consequence, both sides have difficulty communicating effectively about the underlying problems and feelings surrounding self-harm ...
Bijl, J. van der, Kerkhof, A.J.F.M., Koekkoek, B., Kool, N., Meijel, B. van   +4 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Adolescents at risk of self-harm in Ghana: a qualitative interview study exploring the views and experiences of key adult informants

BMC Psychiatry, 2020
Background In Ghana, rates of self-harm in young people are as high as they are in high income countries. Self-reported interpersonal, familial and societal stressors form the most important background, and self-harm is seen by young people as a way of ...
Emmanuel N-B. Quarshie, Mitch G. Waterman, Allan O. House   +2 more
doaj   +1 more source

The prevalence of previous self-harm amongst self-poisoning patients in Sri Lanka [PDF]

, 2010
Background One of the most important components of suicide prevention strategies is to target people who repeat self-harm as they are a high risk group.
Fahim Mohamed, Aravinda Perera, Kusal Wijayaweera, Keerthi Kularatne, Shaluka Jayamanne, Michael Eddleston, Andrew Dawson, Flemming Konradsen, David Gunnell, SJ Taylor, K Skegg, D Owens, K Hawton, GL Carter, D Silva De, W Hoek van der, R Ganeshamoorthy, S Samaraweera, G Gururaj, R Abeyasinghe, MR Phillips, D Gunnell, HJ Silva de, M Eddleston, DJ Gunnell, D Gunnell, RS Spicer, M Thomas, S Singh   +28 more
core   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The Lancet Commission on self-harm

The Lancet
Self-harm is when someone hurts themselves on purpose, regardless of the reasons for doing this. Often, shame and stigma stop people from seeking help. Self-harming behaviour increases the risk of death by suicide, and it is a common cause of disability in young people.
Moran, Paul, Chandler, Amy, Dudgeon, Pat, Kirtley, Olivia J, Knipe, Duleeka, Pirkis, Jane, Sinyor, Mark, Allister, Rosie, Ansloos, Jeffrey, Ball, Melanie A, Chan, Lai Fong, Darwin, Leilani, Derry, Kate L, Hawton, Keith, Heney, Veronica, Hetrick, Sarah, Li, Ang, Machado, Daiane B, McAllister, Emma, McDaid, David, Mehra, Ishita, Niederkrotenthaler, Thomas, Nock, Matthew K, O'Keefe, Victoria M, Oquendo, Maria A, Osafo, Joseph, Patel, Vikram, Pathare, Soumitra, Peltier, Shanna, Roberts, Tessa, Robinson, Jo, Shand, Fiona, Stirling, Fiona, Stoor, Jon PA, Swingler, Natasha, Turecki, Gustavo, Venkatesh, Svetha, Waitoki, Waikaremoana, Wright, Michael, Yip, Paul SF, Spoelma, Michael J, Kapur, Navneet, O'Connor, Rory C, Christensen, Helen   +43 more
openaire   +5 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Resilience revisited: a systematic review and synthesis of Non-Suicidal Self-Injury (NSSI) and its relation with resilience

BMC Psychiatry
Background The aim of the current study is to examine the relationship between nonsuicidal self-injury (NSSI) and resilience. Resilience has been identified as a critical area for further investigation in the context of NSSI.
Daphne Weedage, Nienke Kool-Goudzwaard, Dwayne Meijnckens, Robert R. J. M. Vermeiren, Cyril Boonmann   +4 more
doaj   +1 more source

Suicide and self-harm in Britain: researching risk and resilience using UK surveys [PDF]

, 2019
Aim The main aim of this study was to raise awareness of surveys that could be used to inform self-harm and suicide prevention work. We asked: What UK survey datasets are available for research?
Bennett, C., Gill, V., Gunnell, D., Lubian, K., McManus, S., Porter, L., Turley, C., Weich, S.   +7 more
core   +2 more sources

Cues and knowledge structures used by mental-health professionals when making risk assessments [PDF]

, 2008
Background: Research into mental-health risks has tended to focus on epidemiological approaches and to consider pieces of evidence in isolation. Less is known about the particular factors and their patterns of occurrence that influence clinicians’ risk ...
Ann Adams, Bouch J., Buckingham C. D, Buckingham C. D., Buzan T, Carter G., Castle K., Chris Mace, Christopher D. Buckingham, Dick P., Doctor R, Hanson R. K, Harris E. C., Higgins N., Holdsworth N., Maden A, Mays N., Monahan J., Morgan H. G., Morgan H. G., Muehlenkamp J. J, Neuendorf K, Owens D., Ryan T, Skegg K, Stengel E, Szmukler G, Watts D.   +27 more
core   +3 more sources