Results 91 to 100 of about 3,429,470 (304)
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
BMC Psychiatry, 2020 Background In Ghana, rates of self-harm in young people are as high as they are in high income countries. Self-reported interpersonal, familial and societal stressors form the most important background, and self-harm is seen by young people as a way of ...
Emmanuel N-B. Quarshie +2 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Self-harm in a mixed clinical population: the roles of self-criticism, shame, and social rank [PDF]
, 2010 Objectives. This study explored the relationship of forms and functions of self-criticism, shame, and social rank variables to self-harm, depression, and anxiety. Design. The study used a questionnaire design. Method.
Christie, Rachael +7 more
core +1 more source
The Lancet Commission on self-harm
The LancetSelf-harm is when someone hurts themselves on purpose, regardless of the reasons for doing this. Often, shame and stigma stop people from seeking help. Self-harming behaviour increases the risk of death by suicide, and it is a common cause of disability in young people.
Moran, Paul +43 more
openaire +5 more sources
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
BMC PsychiatryBackground The aim of the current study is to examine the relationship between nonsuicidal self-injury (NSSI) and resilience. Resilience has been identified as a critical area for further investigation in the context of NSSI.
Daphne Weedage +4 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
An exploration of triadic family relationships: a systemic-attachment perspective on the experiences of adolescents who self-harm and their parents [PDF]
, 2013 Self-harm as an expression of emotional pain and hurt is starting to become the consensus view amongst professionals. This present study explored how young people who self-harm and their parents experience the young person’s self-harm and how it affects ...
Karamat Ali, Ramón
core
The epidemiology of self-harm in a UK wide primary care patient cohort, 2001-2013 [PDF]
, 2016 BackgroundMost of the research conducted on people who harm themselves has been undertaken in secondary healthcare settings. Little is known about the frequency of self-harm in primary care patient populations.
Chew-Graham
core +1 more source