Results 71 to 80 of about 330,215 (300)

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Factors associated with deliberate self-harm among Irish adolescents [PDF]

open access: yes, 2010
Background. Deliberate self-harm (DSH) is a major public health problem, with young people most at risk. Lifetime prevalence of DSH in Irish adolescents is between 8% and 12%, and it is three times more prevalent among girls than boys.
Arensman, Ella   +5 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Update on depression and deliberate self-harm

open access: yesSri Lanka Journal of Psychiatry, 2010
DOI:10.4038/sljpsyc.v1i2.2580                             SL J Psychiatry 2010; 1 (2):70 ...
Shehan Williams, Thilini Rajapakse
doaj   +1 more source

Depression and Self-Harm Risk Assessment in Online Forums

open access: yes, 2017
Users suffering from mental health conditions often turn to online resources for support, including specialized online support communities or general communities such as Twitter and Reddit.
Cohan, Arman   +2 more
core   +1 more source

Emotional abuse in sport: A case study of trichotillomania in a prepubescent female gymnast [PDF]

open access: yes, 2013
This article is made available through the Brunel Open Access Publishing Fund. Copyright @ 2013 Gervis M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use ...
Gervis, M, Godfrey, R
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

The relationship between self-harm and bullying behaviour: results from a population based study of adolescents

open access: yesBMC Public Health, 2021
Background This study aims to better understand the association between bullying behaviour (the bullied, the bullies and the bully-victims) and self-harm, and which protective factors moderate this association. Methods A total of 16,182 adolescents, aged
Ingri Myklestad, Melanie Straiton
doaj   +1 more source

Non-Suicidal Self-Injury and Suicidal Behaviour in Children and Adolescents Accessing Residential or Intensive Home-Based Mental Health Services [PDF]

open access: yes, 2012
Objective: There is a dearth of Canadian research with clinical samples of youth who self-harm, and no studies could be located on self-harm in children and youth accessing residential or intensive home-based treatment.
Ashbourne, Graham   +9 more
core   +2 more sources

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