Results 71 to 80 of about 4,955,242 (273)

Prevalence and risk factors for repetition of non-fatal self-harm in Hong Kong, 2002–2016: A population-based cohort study

The Lancet Regional Health. Western Pacific, 2020
Background: A history of self-harm is strongly associated with future self-harm attempts. Large-scale Asian cohort studies examining risk factors for repeated self-harm are lacking. This paper reports on annual prevalence, cumulative risk, annual risk of
Yi Chai, Hao Luo, Paul S.F. Yip
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Adolescents at risk of self-harm in Ghana: a qualitative interview study exploring the views and experiences of key adult informants

BMC Psychiatry, 2020
Background In Ghana, rates of self-harm in young people are as high as they are in high income countries. Self-reported interpersonal, familial and societal stressors form the most important background, and self-harm is seen by young people as a way of ...
Emmanuel N-B. Quarshie, Mitch G. Waterman, Allan O. House   +2 more
doaj   +1 more source

The Lancet Commission on self-harm

The Lancet
Self-harm is when someone hurts themselves on purpose, regardless of the reasons for doing this. Often, shame and stigma stop people from seeking help. Self-harming behaviour increases the risk of death by suicide, and it is a common cause of disability in young people.
Moran, Paul, Chandler, Amy, Dudgeon, Pat, Kirtley, Olivia J., Knipe, Duleeka, Pirkis, Jane, Sinyor, Mark, Allister, Rosie, Ansloos, Jeffrey, Ball, Melanie A., Chan, Lai Fong, Darwin, Leilani, Derry, Kate L., Hawton, Keith, Heney, Veronica, Hetrick, Sarah, Li, Ang, Machado, Daiane B., Mcallister, Emma, Mcdaid, David, Mehra, Ishita, Niederkrotenthaler, Thomas, Nock, Matthew K., O'Keefe, Victoria M., Oquendo, Maria A., Osafo, Joseph, Patel, Vikram, Pathare, Soumitra, Peltier, Shanna, Roberts, Tessa, Robinson, Jo, Shand, Fiona, Stirling, Fiona, Stoor, Jon P.A., Swingler, Natasha, Turecki, Gustavo, Venkatesh, Svetha, Waitoki, Waikaremoana, Wright, Michael, Yip, Paul S.F., Spoelma, Michael J., Kapur, Navneet, O'Connor, Rory C., Christensen, Helen   +43 more
openaire   +5 more sources

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Resilience revisited: a systematic review and synthesis of Non-Suicidal Self-Injury (NSSI) and its relation with resilience

BMC Psychiatry
Background The aim of the current study is to examine the relationship between nonsuicidal self-injury (NSSI) and resilience. Resilience has been identified as a critical area for further investigation in the context of NSSI.
Daphne Weedage, Nienke Kool-Goudzwaard, Dwayne Meijnckens, Robert R. J. M. Vermeiren, Cyril Boonmann   +4 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source