Results 81 to 90 of about 269,208 (299)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Self‐Healing Hydrogels: Mechanisms and Biomedical Applications

MedComm
Hydrogels have emerged as dependable candidates for tissue repair because of their exceptional biocompatibility and tunable mechanical properties. However, conventional hydrogels are vulnerable to damage owing to mechanical stress and environmental ...
Lingling Xue, Ran An, Junqi Zhao, Mengdi Qiu, Zhongxia Wang, Haozhen Ren, Decai Yu, Xinhua Zhu   +7 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Toughening Self‐Healing Elastomers with Chain Mobility

Advanced Science
Enhancing fracture toughness and self‐healing within soft elastomers is crucial to prolonging the operational lifetimes of soft devices. Herein, it is revealed that tuning the polymer chain mobilities of carboxylated‐functionalized polyurethane through ...
Matthew Wei Ming Tan, Patrick Michael Thornton, Gurunathan Thangavel, Hyunwoo Bark, Reinhold Dauskardt, Pooi See Lee   +5 more
doaj   +1 more source

The Influence of Calcium-Based Whisker Self-Healing Agent on Self-Healing of Oil Well Set Cement Cracks in CCUS Wells

Zuanjingye yu wanjingye
In wells for carbon capture, utilization and storage (CCUS), cement sheaths are easy to get chemically damaged, hence reducing their service life. A study was conducted to enhance the self-healing capacity of cement sheaths by reacting calcium-based ...
Hongchang CAO, Donghong DANG, Ye ZHANG, Qiang REN, Jingli LIU, Yan LIU, Song PENG, Jun MA   +7 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Humidity‐Induced Self‐Oscillating and Self‐Healing Hypercrosslinked Metal–Organic Polyhedra Membranes

Advanced Science
Designing autonomously oscillating materials is highly desirable for emerging smart material fields but challenging. Herein, a type of hypercrosslinked metal–organic polyhedra (HCMOPs) membranes formed by covalent crosslinking of boronic acid‐modified Zr‐
Jiamin Li, Zhaoyi Liu, Jinjin Liu, Xue Liu, Yang Luo, Jiajie Liang, Zhenjie Zhang   +6 more
doaj   +1 more source

Recent Advances of Self-Healing Materials for Civil Engineering: Models and Simulations

Buildings
Empowering materials with self-healing capabilities is an attractive approach for sustainable development. This strategy involves using different methods to automatically heal microcracks and damages that occur during the service life of materials or ...
Cen-Ying Liao, Lin Zhang, Si-Yu Hu, Shuai-Jie Xia, D. M. Li   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source