Results 91 to 100 of about 3,992,332 (307)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Kenōsis in sexuality

open access: yesVerbum et Ecclesia, 2013
Recent decades have witnessed both a shift in sexual standards, and the loss of the Biblical authority which has traditionally motivated them. This has been the case even with Christians.
David T. Williams
doaj  

Investigating self-concept and health-related quality of life

open access: yes, 2006
Health-related quality of life has been an important topic of research in diverse fields such as medicine, nursing, community service provision and psychology.
Dowson, Martin   +2 more
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

The measurement of multidimensional self-concept in adults with mild intellectual disability

open access: yes, 2006
Although self-concept is now recognised as a multidimensional construct, unidimensional measurement is still common practise for adults with mild intellectual disabilities.
Craven, Rhonda   +2 more
core  

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

The School of Bunesti, Arges, Romania: Hand-made Architecture, A Craft of Self-limitation

open access: yesJournal of Traditional Building, Architecture and Urbanism
Weary of the present-day inflation of possibilities for planning, building, learning, and living, and with an increasingly acute sense of the artificiality of our professional training, we—a historian, an architect, and a small group of students—chose ...
Ana Maria Goilav
doaj   +1 more source

Multifaceted self-concept of indigenous Australian secondary students : structure and relations to other academic variables

open access: yes, 2006
In response to recent calls for the development of culturally relevant and applicable quantitative instruments for research into the educational disadvantages suffered by Indigenous Australian students, Bodkin-Andrews, Craven & Marsh (2005) analysed the ...
Craven, Rhonda, Bodkin-Andrews, Gawaian
core  

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

Characteristics of disability in activity of daily living in elderly people associated with locomotive disorders

open access: yesBMC Geriatrics, 2017
Background Ageing is associated with a decline of motor function and ability to perform daily activities. Locomotive disorders are one of the major disorders resulting in adverse health condition in elderly people.
Tsutomu Iwaya   +5 more
doaj   +1 more source

Home - About - Disclaimer - Privacy