Results 71 to 80 of about 5,284,802 (285)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Emotional Distress May Increase Risk for Self-Medication and Lower Risk for Mood-related Drinking Consequences in Adolescents [PDF]

, 2012
The current study examines indicators of emotional distress and coping that may define sub-populations of adolescents at risk for two potential affect-related mechanisms underlying substance misuse: self-medication and mood-related drinking consequences.
Feagans Gould, Laura, Hersh, Matthew A., Matthew A. Hersh, Laura Feagans, Andrea M. Hussong, Hussong, Andrea M.   +5 more
core   +1 more source

Development of a new diabetes medication self-efficacy scale and its association with both reported problems in using diabetes medications and self-reported adherence [PDF]

, 2016
Betsy Sleath,1,2 Delesha M Carpenter,1 Susan J Blalock,1 Scott A Davis,1 Ryan P Hickson,1 Charles Lee,3 Stefanie P Ferreri,4 Jennifer E Scott,5 Lisa B Rodebaugh,6 Doyle M Cummings6,7 1Division of Pharmaceutical Outcomes and Policy, UNC Eshelman School ...
Hickson RP, Carpenter, Delesha M., Scott, Jennifer E, Rodebaugh, Lisa B, Carpenter DM, Sleath, Betsy, Davis SA, Lee C, Hickson, Ryan P., Ferreri, Stefanie P., Blalock SJ, Lee, Charles, Rodebaugh, Lisa B., Sleath B, Davis, Scott A, Davis, Scott A., Blalock, Susan J., Rodebaugh LB, Cummings, Doyle M., Blalock, Susan J, Scott JE, Ferreri SP, Scott, Jennifer E., Cummings DM, Hickson, Ryan P, Ferreri, Stefanie P, Carpenter, Delesha M   +26 more
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Emotional dysfunction in schizophrenia spectrum psychosis: the role of illness perceptions [PDF]

, 2006
Background. Assessing illness perceptions has been useful in a range of medical disorders. This study of people with a recent relapse of their psychosis examines the relationship between illness perception, their emotional responses and their attitudes ...
Garety, PA, Bebbington, P E, P. W. B. Watson, Freeman, D, Weinman, J, Weinman, J., Fowler, D., Dunn, G., Dunn, G, Bebbington, PE, D. Fowler, J. Weinman, G. Dunn, Garety, P A; id_orcid, Kuipers, E; id_orcid, Watson, PWB, Watson, PW, Fowler, D, Kuipers, E, Watson, P W B, E. Kuipers, Watson, P. W. B., Freeman, D., Bebbington, P. E., Freeman, Daniel, P. E. Bebbington, D. Freeman, P. A. Garety, Garety, P. A., Kuipers, E.   +29 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Self-Medication Behavior: Self-Medication Behavior

Journal of Midwifery and Nursing, 2020
In developing countries self-medication behavior is something that is very often found. This happens because self-medication behavior provides a cheaper and easier alternative for the community. Coupled with the ease in purchasing drugs. Self-medication is usually done to overcome complaints and minor illnesses that are often experienced by the ...
openaire   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Self-medication among medical students in Anbar and Fallujah Universities – Iraq

مجلة كلية الطب, 2018
Background: Self-medication (SM) is a worldwide issue, that has serious adverse effects on individuals and communities. Objective:  To estimate the prevalence of self- medication   among medical student in Anbar and Falluja Universities and to explore
Ameel F. Al Shawi, Ahmed F. Ali, Murtadha M. Enad,  Junaid A. Salih   +3 more
doaj   +1 more source