Results 61 to 70 of about 157,060 (311)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Drilling Performance of Self-propelled Straight-Rotary Mixing Nozzle

Shiyou jixie, 2022
In order to improve the application results of hydraulic radial drilling technology in hydrate exploitation and reservoir stimulation,numerical simulation method was used to study the drilling performance of self-propelled nozzle,which is the core ...
Gao Junhong, Fu Biwei, Dong Zongzheng
doaj  

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Experimental study and sub-channel analysis on the transverse mixing of the helical cruciform fuel assembly

Nuclear Engineering and Technology
The helical cruciform fuel (HCF) is characterized as self-mixing and self-supporting, which has promising applications in advanced nuclear power devices.
Qi Zhang, Zhenhai Liu, Yile Zhang, Hua Pang, Mengke Cai, Zhenhan Hong, Guangliang Yang, Haoyu Wang, Li Liu, Yao Xiao, Hanyang Gu   +10 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Sub 15 ps Self Mode-Locked Nd:YVO4 Laser through Intra-Cavity Sum-Frequency Mixing [PDF]

EPJ Web of Conferences, 2022
Brunzell Martin, Widarsson Max, Laurell Fredrik, Pasiskevicius Valdas   +3 more
doaj   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Self-mixing signals in terahertz lasers

COMMAD 2012, 2012
Recently demonstrated self-mixing effect in terahertz quantum cascade lasers (QCL) opens new possibilities for detectorless sensing in this range of electromagnetic spectrum. In this paper we compare self-mixing signals obtained from variations in QCL terminal voltage against the signals obtained from variations in QCL radiated power monitored using a ...
Lim, YL, Bertling, K, Dean, P, Valavanis, A, Alhathlool, R, Khanna, SP, Indjin, D, Linfield, EH, Davies, AG, Wilson, SJ, Rakic, AD   +10 more
openaire   +3 more sources

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Microfluidic and Turbulent Mixing for mRNA LNP Vaccines

Pharmaceutics
Using lipid nanocarriers to deliver the mRNA of a specific antigen to immune cells is a powerful innovative approach to rapidly develop new safe and effective vaccines.
Patrick L. Ahl
doaj   +1 more source