Results 61 to 70 of about 571,969 (257)

Book publishing in Vyatka region in the early XX century

open access: yesБиблиосфера, 2017
The Russian government in the field of extracurricular education in the early XX century persuded certain goals: preserving the state foundations inviolability, spreading the Orthodoxy tenets, raising the people cultural level.
Yu. V. Pershina
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Vom Urheber zur Crowd, vom Werk zur Version, vom Schutz zur Öffnung? Kollaboratives Schreiben und Bewerten in den Digital Humanities

open access: yesZeitschrift für digitale Geisteswissenschaften, 2015
Open review projects and wikis are changing academic knowledge production, just as academic blogs and social media are influencing scholarly communication.
Thomas Ernst
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

You don’t know what you’ve got till it’s gone: the changing landscape of UK learned society publishing

open access: yesInsights: The UKSG Journal
This study draws on a longitudinal dataset of 277 UK learned societies covering the period 2015–2023 to provide evidence-based insights into the changing landscape of society publishing.
Rob Johnson, Elle Malcolmson
doaj   +1 more source

Science Communication: Self-Publishing's Benefits [PDF]

open access: yesScience, 2013
The News story “The seer of science publishing” (T. Rabesandratana, special section on Communication in Science, 4 October, p. [66][1]) draws attention to F1000Research , a journal offering immediate publication with post-publication peer review and revision. The idea of post-publication review is not new. Fifteen years ago I launched naturalSCIENCE (
openaire   +2 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

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