Results 51 to 60 of about 335,406 (261)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Factors associated with poor self-reported health within the UK military and comparisons with the general population: a cohort study

JRSM Open, 2017
Objective To investigate the self-rated health of the UK military and explore factors associated with poor self-rated health. Compare self-rated health of the military to the general population. Design A cohort study. Participants A total of 7626 serving
Sarah C Jenkins, Sharon AM Stevelink, Nicola T Fear   +2 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Analysis of the mediating role of life style in the relationship between health literacy and self-rated health employing structural equation modeling

Scientific Reports
Self-rated health is related to the reduction of the burden of diseases and health outcomes. Various factors affect self-rated health. This study aimed to investigate the mediating role of life style in the relationship between health literacy and self ...
Mansour Bagherinia, Shahab Rezaeian, Ebrahim Shakiba, Raheleh Maleki, Abbas Mohammad Karimi Mazhin, Hadi Darvishigilan, Maryam Janatolmakan, Badriyeh Karami   +7 more
doaj   +1 more source

IMPORTANCE OF SELF-RATED HEALTH AS A HEALTH INDICATOR

Praxis medica, 2010
<p>Because of significance of self-rated health as a valid measure of health status it is important to research what influence on individuals when they assess own health.. The aims of the study were to investigate how north Kosovska Mitrovica adults describe their health and to compare results with results from Serbia without Kosovo and ...
M. Mirković, S. Simić, J. Marinković, M. Parlić, M. Parlić, A. Ćorac, S. Ðurić   +6 more
openaire   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Is self-esteem associated with self-rated health among French college students? A longitudinal epidemiological study: the i-Share cohort

BMJ Open, 2019
ObjectivesThe aim of the study was to estimate the association between self-esteem and subsequent self-rated health during college years, taking into account a wide range of potential confounders.DesignProspective longitudinal study.SettingThe French i ...
Julie Arsandaux, Grégory Michel, Marie Tournier, Christophe Tzourio, Cédric Galéra   +4 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Characteristics and self-rated health of overlap syndrome

International Journal of Chronic Obstructive Pulmonary Disease, 2014
Overlap syndrome shares features of both asthma and chronic obstructive pulmonary disease (COPD). The aim of this study was to investigate characteristics of overlap syndrome and their effect on self-rated health (SRH).We analyzed data from the Fourth Korea National Health and Nutrition Examination Survey of 2007-2009.
Chung,Jung Wha, Kong,Kyoung Ae, Lee,Jin Hwa, Lee,Seok Jeong, Ryu,Yon Ju, Chang,Jung Hyun   +5 more
openaire   +4 more sources