Results 51 to 60 of about 5,139,684 (305)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Association between self-regulatory modes and alexithymia mediated by mindfulness and cognitive reappraisal

open access: yesScientific Reports
This research examined alexithymia through the lens of personality as a dynamic regulatory system and focused on the ways in which two distinct self-regulatory modes, assessment and locomotion, are linked to alexithymia.
Idit Shalev, Erez Yaakobi
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Comparing Certification and Self-Regulation [PDF]

open access: yesSSRN Electronic Journal, 2008
I compare certification and self-regulation, two widely used quality assurance mechanisms in markets where consumers do not observe the quality of goods. Certification is a mechanism in which an external firm offers a certificate to producers who undergo a testing procedure, issues the certificate if they meet the certifier's standards and collects the
openaire   +2 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Relationship Between Self Efficacy And Self Regulation In Diabetes Mellitus Patients

open access: yesProfessional Health Journal
Diabetes Mellitus is an incurable disease that affects aspects of life and increases the risk of complications that can cause death. Complications can be minimized if the patient has compliance, knowledge, and ability to perform self-care .
Devi Setya Putri   +2 more
doaj   +1 more source

Understanding medical student evidence-based medicine information seeking in an authentic clinical simulation

open access: yesJournal of the Medical Library Association, 2020
Objective: Evidence-based medicine practices of medical students in clinical scenarios are not well understood. Optimal foraging theory (OFT) is one framework that could be useful in breaking apart information-seeking patterns to determine effectiveness ...
Joey Nicholson   +3 more
doaj   +1 more source

The Investigation of Iranian Learners’ CALL Attitude and Its Relationship with Academic Self-Regulation in Learning EFL [PDF]

open access: yesFanāvarī-i āmūzish, 2013
: The present study was designed to find out the relationship between Iranian junior high-school learners’ attitudes towards CALL and academic self-regulation in learning English as a foreign language. Two hundred and thirteen junior high-school students
M. Meshkat, S. Foroozeshnia
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

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