Results 91 to 100 of about 316,545 (267)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Elliptic Self Similar Stochastic Processes [PDF]

open access: yesRevista Matemática Iberoamericana, 1999
Let M be a random measure and L be an elliptic pseudo-differential operator on \mathbb{R}^d
Benassi, Albert, Roux, Daniel
openaire   +3 more sources

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Self-Similarity and Symmetry With SIFT for Multi-Modal Image Registration

open access: yesIEEE Access, 2019
This paper presents a novel feature-based multi-modal image registration technique called self-similarity and symmetry with a scale invariant feature transform (3S-SIFT). The proposed technique has the following two main components.
Guohua Lv
doaj   +1 more source

Log-periodic self-similarity: an emerging financial law?

open access: yes, 2002
A hypothesis that the financial log-periodicity, cascading self-similarity through various time scales, carries signatures of a law is pursued. It is shown that the most significant historical financial events can be classified amazingly well using a ...
Ball   +20 more
core   +3 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

From Self-Similar Groups to Self-Similar Sets and Spectra [PDF]

open access: yes, 2015
The survey presents developments in the theory of self-similar groups leading to applications to the study of fractal sets and graphs, and their associated spectra.
Grigorchuk, Rostislav   +2 more
openaire   +2 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Free Decay of Turbulence and Breakdown of Self-Similarity

open access: yes, 1999
It has been generally assumed, since the work of von Karman and Howarth in 1938, that free decay of fully-developed turbulence is self-similar. We present here a simple phenomenological model of the decay of 3D incompressible turbulence, which predicts ...
Eyink, Gregory L., Thomson, David J.
core   +1 more source

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