Results 111 to 120 of about 4,640,261 (249)

Evaluation of Digital Technologies for Home‐Based Assessment in People With Amyotrophic Lateral Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller   +14 more
wiley   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

A systematic literature review of factors influencing national food self-sufficiency

open access: yesSustainable Futures
Global shocks, such as the COVID-19 pandemic and the war in Ukraine, have put food self-sufficiency (i.e., the ratio between domestic production and domestic consumption) back on the political agenda in heavily food importing countries.
Christian Ritzel
doaj   +1 more source

Non-monotonic utility functions for microeconomic analysis of sufficiency economy [PDF]

open access: yes
This study invents four types of non-monotonic utility functions that suit the sufficiency economy. With these utility functions, an individual may not get higher utility when consume more goods.
Suriya, Komsan
core  

Bi‐ and Mono‐Allelic RFC1 Expansion in a North American Cohort With Idiopathic Axonal Neuropathy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective RFC1 biallelic repeat expansion is increasingly recognized as a cause of chronic idiopathic axonal polyneuropathy (CIAP), but it remains challenging to know who to test. This study aims to determine the prevalence of biallelic and monoallelic RFC1 expansions and their corresponding neuropathy phenotypes in CIAP patients and identify ...
Amro M. Stino   +25 more
wiley   +1 more source

A new method for calculating the food self-sufficiency ratio: supply-side food self-sufficiency ratio

open access: yesAgriculture & Food Security
Background The conventional food self-sufficiency ratio (CFSSR), which primarily focuses on grains, fails to capture the full spectrum of daily food consumption.
Goro Takahashi
doaj   +1 more source

Growing utopia – undoing risk through self-sufficiency and urban gardening?

open access: yes
This paper analyses how the utopia of self-sufficiency functions as a response to risk and uncertainty. Recent decades have witnessed the proliferation of risk.
Montelius, Elin,
core   +1 more source

Factors Associated With the Rising Trend in Self‐Reported Cognitive Disability Among U.S. Adults Aged 18–39 From 2013–2024

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Building on our prior Behavioral Risk Factor Surveillance System analysis identifying adults aged 18–39 as the primary driver of the national increase in self‐reported cognitive disability, we examined factors associated with this rise using 2013–2024 U.S. BRFSS data. Methods We analyzed U.S.
Adam de Havenon   +9 more
wiley   +1 more source

Morphology Optimization of Residential Communities towards Maximizing Energy Self-Sufficiency in the Hot Summer Cold Winter Climate Zone of China

open access: yesLand
Further research is needed on the capability of residential communities to achieve energy self-sufficiency under the constraints of current standards of land use, in particular for the Hot Summer and Cold Winter climate zone (HSCW) of China, where the ...
Yuan Zhou   +3 more
doaj   +1 more source

DETERMINANTS SELF SUFFICIENCY OF RICE IN SUPPORTING FOOD INDEPENDENCE [PDF]

open access: yes, 2019
The research objective is to determine the future trends of rice self-sufficiency and to know the factors that influence rice self-sufficiency so as to achieve food independence.
Iskandar, Deden Dinar   +1 more
core  

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