Results 51 to 60 of about 4,767,213 (297)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Dimensions of Self-Sufficiency
, 2013 This working paper addresses two dimensions in which transnational or supranational regulatory regimes may be regarded as self-sufficient, providing some reasons, limits and pitfalls from such a tendency. The focus of both parts is on competition policy, which is of particular importance because of its transversal character: the fact that it can be ...
openaire +2 more sources
Self-sufficient sets in smartgrids
Electronic Notes in Discrete Mathematics, 2018 Abstract We consider the problem of finding microgrids in a network. We mainly focus on the complexity aspects related to the different variants of this problem5.
J. David +3 more
openaire +2 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Regional non-equilibrium characteristics and spatial convergence of China’s self-sufficiency rate of rations [PDF]
Ziyuan Kexue[Objective] This article discussed the regional differences and spatial convergence of ration security from the perspectives of consumption and demand, in order to provide a scientific basis for each region to better assume the due responsibility of ...
YANG Yidan, YAO Chengsheng, GAO Yunpeng, LIU Weifang
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Self-sufficiency of agriculture in Finland in 1970—1983
Agricultural and Food Science, 1986 This study is aimed at considering self-sufficiency and food security in Finland. Self-sufficiency of final products has been over 100 % for a long period. Only self-sufficiency of fruits and vegetables is below 100 % due to the climate. Self-sufficiency
Lauri Kettunen
doaj
Long-Term Agricultural Development Problems of the Russian Far East [PDF]
Пространственная экономика, 2012 The article considers the problems of long-term agricultural development and prospects of scientifictechnical and technological modernization. The author justifies two versions of the perspective agricultural development and opportunities for the local ...
Grigory Isakovich Sukhomirov +1 more
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source