Results 51 to 60 of about 34,332 (263)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Self-sufficiency of agriculture in Finland in 1970—1983

Agricultural and Food Science, 1986
This study is aimed at considering self-sufficiency and food security in Finland. Self-sufficiency of final products has been over 100 % for a long period. Only self-sufficiency of fruits and vegetables is below 100 % due to the climate. Self-sufficiency
Lauri Kettunen
doaj  

Long-Term Agricultural Development Problems of the Russian Far East [PDF]

Пространственная экономика, 2012
The article considers the problems of long-term agricultural development and prospects of scientifictechnical and technological modernization. The author justifies two versions of the perspective agricultural development and opportunities for the local ...
Grigory Isakovich Sukhomirov , Alexey Semyonovich Shelepa   +1 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Simulasi Kebijakan Penambahan Areal Tanam dan Peningkatan Produktivitas dalam Mendukung Tercapainya Swasembada Jagung

Agritech, 2019
Corn is one of five main commodities that is expected to achieve self-sufficiency at the end of RPJMN 2019. However, the gap between supply and demand capacities was still quite large, so that imports are still conducted.
Parama Tirta Wulandari Wening Kusuma, Didik Junaedi Rachbini   +1 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Global organ shortage: an analysis of national self‑sufficiency strategies

Вестник трансплантологии и искусственных органов, 2020
From the standpoint of socio-humanitarian knowledge, the paper analyzes the problem of global organ shortage. The basic ideas of the international medical community about organ shortage and the main proposals for overcoming it are considered.
O. N. Reznik, D. V. Mikhel
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Assessing land use change from food croplands to rubber in Ghana's Ellembelle district: Implications for food self-sufficiency

Scientific African
There is evidence that cocoa and cashew farmers are targeting croplands for expansion, reducing cropland areas with negative implications for food self-sufficiency in Ghana. However, research on the dynamics of rubber expansion and its possible impact on
George Ashiagbor, Victor Quarshie, Sandra Sawdiatu Inusah, Isaac Stanisluv Essah, Sinka Khadijah Abubakar, Erasmus Narteh Tetteh, Winston Adams Asante   +6 more
doaj   +1 more source