Results 71 to 80 of about 4,508,283 (303)
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
The self-sufficiency standard for Connecticut 2015
, 2015 "September 2015."; Previously issued: The real cost of living in 2005 : the self-sufficiency standard for Connecticut / by Diana Pearce ; prepared for Office of Workforce Competitiveness, State of Connecticut. [Hartford] : State of Connecticut, Office of
Pearce, Diana,
core +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Urban-rural relations in renewable electric energy supply – the case of a German energy region
International Journal of Sustainable Energy Planning and Management, 2019 The study analyzes the cross-linking of urban and rural regions in terms of synergies between electric energy supply from renewables and electric energy demand by taking the example of a German energy region.
Caroline Möller +2 more
doaj +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
La question de l’autosuffisance protéique est-elle définitivement obsolète pour l’Union Européenne ?
Oléagineux, Corps gras, Lipides, 2005 Is the issue of European self-sufficiency in vegetal proteins definitely obsolete? The issue is reviewed from two standpoints: economic relevance and political feasibility in regards to international relations.
Mahé Louis-Pascal
doaj +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
Comparative Advantage, Self-sufficiency and Food Security in Iran: Case Study of Wheat Commodity [PDF]
International Journal of Agricultural Management and Development, 2014 Food security has a dynamic notion during the time and may be affected by various domestic and global factors. Nevertheless, Iranian policy makers consider food security as same as self-sufficiency in agricultural food products, particularly wheat ...
Mahmood Haji-Rahimi
doaj