Results 51 to 60 of about 3,071,906 (311)
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Agritech, 2019 Corn is one of five main commodities that is expected to achieve self-sufficiency at the end of RPJMN 2019. However, the gap between supply and demand capacities was still quite large, so that imports are still conducted.
Parama Tirta Wulandari Wening Kusuma +1 more
doaj +1 more source
Long-Term Agricultural Development Problems of the Russian Far East [PDF]
Пространственная экономика, 2012 The article considers the problems of long-term agricultural development and prospects of scientifictechnical and technological modernization. The author justifies two versions of the perspective agricultural development and opportunities for the local ...
Grigory Isakovich Sukhomirov +1 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Jurnal Aplikasi Bisnis dan Manajemen, 2023 Smart purchasing behavior is a bright act of a consumer in deciding to use a product. Several studies show that consumer needs and desires contribute to purchasing behavior.
Rana Chyntia Azzara +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Scientific AfricanThere is evidence that cocoa and cashew farmers are targeting croplands for expansion, reducing cropland areas with negative implications for food self-sufficiency in Ghana. However, research on the dynamics of rubber expansion and its possible impact on
George Ashiagbor +6 more
doaj +1 more source
Global organ shortage: an analysis of national self‑sufficiency strategies
Вестник трансплантологии и искусственных органов, 2020 From the standpoint of socio-humanitarian knowledge, the paper analyzes the problem of global organ shortage. The basic ideas of the international medical community about organ shortage and the main proposals for overcoming it are considered.
O. N. Reznik, D. V. Mikhel
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source