Results 111 to 120 of about 20,005,903 (395)

Self-Knowledge and Self-Love [PDF]

open access: yesEthical Theory and Moral Practice, 2015
In this paper I argue for the claim that self-love is a precondition for self-knowledge. This claim is relevant to the contemporary philosophical debate on self-knowledge, but mainly because it draws attention to the role of claims of self-knowledge in the larger context of our ordinary practice of rationalizing and appropriating our actions.
openaire   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Bioinspired Compartmentalization Strategy for Coating Polymers with Self-Organized Prismatic Films

open access: hybrid, 2021
Zhengzheng Li   +13 more
openalex   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

Analysis of Synaptic Scaling in Combination with Hebbian Plasticity in Several Simple Networks

open access: yesFrontiers in Computational Neuroscience, 2012
Conventional synaptic plasticity in combination with synaptic scaling is a biologically plausible plasticity rule that guides the development of synapses towards stability.
Christian eTetzlaff   +4 more
doaj   +1 more source

AGRICULTURAL DEVELOPMENT, STATE EFFECTIVENESS AND LONG-RUN ECONOMIC DEVELOPMENT [PDF]

open access: yes
This paper begins with the presumption that rapid economic development requires an effective state. An effective state is able to act independently of powerful interest groups with the aim of allocating resources so as to maximize long-term economic ...
Richard Grabowski, Sharmistha Self
core  

Williams’s Pragmatic Genealogy and Self-Effacing Functionality [PDF]

open access: yes, 2018
In Truth and Truthfulness, Bernard Williams sought to defend the value of truth by giving a vindicatory genealogy revealing its instrumental value. But what separates Williams’s instrumental vindication from the indirect utilitarianism of which he was a ...
Queloz, Matthieu
core   +2 more sources

Individual Self, Relational Self, Collective Self: Hierarchical Ordering of the Tripartite Self

open access: yesPsychological Studies, 2011
The individual self comprise unique attributes, the relational self comprises partner-shared attributes, and the collective self comprises ingroup-shared attributes. All selves are fundamental components of the self-concept, with each being important and meaningful to human experience and with each being associated with health benefits. Are the selves,
Sedikides, Constantine   +2 more
openaire   +4 more sources

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