Results 101 to 110 of about 12,973,361 (304)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Assessing bullying, being bullied, and self-concept : a psychometric evaluation of the Adolescent Peer Relations Instrument and Self-Description Questionnaire II for upper primary aged children

, 2006
Research on school bullying tends to focus on single-item item rather than scale-based questionnaires, the former of which do not take into consideration the different types of bullying which can take place.
Finger, Linda R., Dowson, Martin, Craven, Rhonda   +2 more
core  

Vital Capacity and Selected Metabolic Diseases in Middle-Aged Japanese Men

Canadian Respiratory Journal, 2006
OBJECTIVE: To elucidate the association between vital capacity and the presence of selected metabolic diseases in middle-aged Japanese men.
Hidenari Sakuta, Takashi Suzuki, Hiroko Yyasuda, Teizo Ito   +3 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Opening doors? Professional self-concept of pre-service teachers in relation to the inclusion of students with disabilities

, 2006
Current research indicates that a key to successful inclusive practices lies in teacher attitudes and preparation. It is proposed that effectively including students with disabilities in mainstream classrooms will be dependent on the focus and content of
Healey, Jean B., Marder, Kurt
core  

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Self Study

, 2013
Department of Political Science Self Study Report for Academic Program ReviewDepartment of Political Science Self Study Report Academic Program ReviewDepartment of Political Science Self Study Report Academic Program ...
Academic Program Review, APR, Political Science, Self Study, Department of Political Science, Self Study Report   +2 more
core  

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Self-concepts of primary students with mild intellectual disabilities : issues of measurement and educational placement

, 2000
The educational placement of students with mild intellectual disabilities remains controversial. Arguments for educational placement are often based upon the anticipated impact upon self-concept.
Tracey, Danielle K. (R13635), Marsh, Herbert W. (R8137)   +1 more
core  

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source