Results 81 to 90 of about 3,429,163 (263)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Motility-induced mixing transition in exponentially growing multicellular spheroids
Communications PhysicsGrowth drives cellular dynamics in dense aggregates, including bacterial colonies, developing tissues, and tumors. However, its effects on other relevant activities have not received sufficient attention.
Torben Sunkel +2 more
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
The Egyptian Journal of Radiology and Nuclear MedicinePolicySegNet is a novel hybrid deep learning architecture developed for joint brain tumor segmentation and classification using MRI scans. It combines a pretrained SegFormer-B4 encoder (with a MiT backbone, originally trained on the ADE20K dataset) as a ...
Vishv Patel +2 more
doaj +1 more source
, 2006 Given the “struggle for existence” an organism might hope to outshine its competitors by virtue of the excellence of its positive characters (e.g. greater speed, longer neck). But an organism that could also (i) identify, defend against, and attack its foes, and (ii) identify and support its friends, wonld seem to have an even greater advantage.
openaire +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
BMC Public HealthBackground Small and medium-sized enterprises (SMEs) employ a considerable proportion of the workforce in many countries. However, little research has specifically explored how SME employees in Canada fare in terms of mental health.
Simon Coulombe +4 more
doaj +1 more source