Results 61 to 70 of about 12,973,361 (304)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Frontiers in Digital HealthBackgroundSemantic interoperability remains a significant barrier in healthcare, particularly when integrating patient-reported, clinical, and genomic data to enable personalized care.
Radha Ambalavanan +5 more
doaj +1 more source
Applied Bionics and Biomechanics, 2022 The aim of this study is to demonstrate the effect of particle size on semiconductor properties; artificial intelligence is being used for the research methods.
Walid Theib Mohammad +11 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Contact numbers in packings of frictional cylinders [PDF]
EPJ Web of ConferencesThe mechanical stability of a granular system depends on the average number of contacts Z between its particles. For most particle shapes, predicting Z as a function of the average volume fraction ϕ is complicated by the spatial correlations between ...
Schröter Matthias +2 more
doaj +1 more source
BMC Women's Health, 2023 Background Almost all women will experience menopause, and the symptoms can have a severely detrimental impact on their quality of life. However, there is limited research exploring health-seeking behaviours and alternative service design or consultation
David Roy Huang +6 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Minimum entropy production by microswimmers with internal dissipation
Nature Communications, 2023 The energy dissipation and entropy production by self-propelled microswimmers differ profoundly from passive particles pulled by external forces.
Abdallah Daddi-Moussa-Ider +2 more
doaj +1 more source