Results 71 to 80 of about 6,428,724 (313)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Support for a reciprocal effects model of self-concept and academic achievement through a contrast of multidimensional and unidimensional approaches

, 2006
There is a longstanding debate in the self-concept literature surrounding the causal ordering of self-concept and academic achievement. Some researchers have argued that self-esteem has no positive impact upon performance (Baumeister, Campbell, Krueger &
Marsh, Herbert W., O'Mara, Alison J.
core  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Comparison of the electrophysiological properties of the pulmonary veins between paroxysmal and persistent atrial fibrillation

Journal of Arrhythmia
Background The role of the pulmonary veins (PVs) as triggers in atrial fibrillation (AF) is well‐known; however, their detailed electrophysiological properties have not been thoroughly examined.
Hitoshi Mori, Akira Hamabe, Daisuke Kawano, Tsukasa Naganuma, Mai Tahara, Yodo Gatate, Toyokazu Kimura, Hirotsugu Tabata, Ritsushi Kato   +8 more
doaj   +1 more source

Investigating self-concept and health-related quality of life

, 2006
Health-related quality of life has been an important topic of research in diverse fields such as medicine, nursing, community service provision and psychology.
Dowson, Martin, Martin, Andrew J., Martinez, Carissa J.   +2 more
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Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Scanning and resetting the phase of a pinned spiral wave using periodic far field pulses

New Journal of Physics, 2016
Spiral waves in cardiac tissue can pin to tissue heterogeneities and form stable pinned waves. These waves can be unpinned by electric stimuli applied close to the pinning center during the vulnerable window of the spiral. Using a phase transition curve (
T K Shajahan, Sebastian Berg, Stefan Luther, Valentin Krinski, Philip Bittihn   +4 more
doaj   +1 more source

The measurement of multidimensional self-concept in adults with mild intellectual disability

, 2006
Although self-concept is now recognised as a multidimensional construct, unidimensional measurement is still common practise for adults with mild intellectual disabilities.
Craven, Rhonda, Martin, Andrew J., Dixon, Roselyn M.   +2 more
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ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Multifaceted self-concept of indigenous Australian secondary students : structure and relations to other academic variables

, 2006
In response to recent calls for the development of culturally relevant and applicable quantitative instruments for research into the educational disadvantages suffered by Indigenous Australian students, Bodkin-Andrews, Craven & Marsh (2005) analysed the ...
Craven, Rhonda, Bodkin-Andrews, Gawaian
core