Results 91 to 100 of about 14,359,458 (301)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Journal of ArrhythmiaBackground The role of the pulmonary veins (PVs) as triggers in atrial fibrillation (AF) is well‐known; however, their detailed electrophysiological properties have not been thoroughly examined.
Hitoshi Mori +8 more
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Checkpoint blockade and the stem‐like T cell trade‐off
Molecular Oncology, EarlyView.Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley +1 more source
Vital Capacity and Selected Metabolic Diseases in Middle-Aged Japanese Men
Canadian Respiratory Journal, 2006 OBJECTIVE: To elucidate the association between vital capacity and the presence of selected metabolic diseases in middle-aged Japanese men.
Hidenari Sakuta +3 more
doaj +1 more source
BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma
FEBS Open Bio, EarlyView.The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru +6 more
wiley +1 more source
The Study of the Effects of the Regular Exercise Program on the Self-Esteem of the Elderly in the Old People Home of Rasht [PDF]
Background & Objectives: Regarding the importance of improving the health of elderly and the relationship between the physical performance and self-esteem, this tudy was done with the aim of determining the effect of the regular exercise programs on ...
شهباززادگان, بیتا +3 more
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Self-Knowledge and Self-Love [PDF]
Ethical Theory and Moral Practice, 2015 In this paper I argue for the claim that self-love is a precondition for self-knowledge. This claim is relevant to the contemporary philosophical debate on self-knowledge, but mainly because it draws attention to the role of claims of self-knowledge in the larger context of our ordinary practice of rationalizing and appropriating our actions.
openaire +2 more sources
FEBS Open Bio, EarlyView.The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida +6 more
wiley +1 more source
Robustness of ballistic transport in antidot superlattices
New Journal of Physics, 2019 The magneto-resistance of antidot lattices shows pronounced peaks, which became a hallmark of ballistic electron transport. While most studies agree that they reflect the interplay of regular and chaotic motion in the quasi-classical dynamics, the exact ...
George Datseris +2 more
doaj +1 more source