Results 51 to 60 of about 11,204,895 (316)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating facilitators and barriers to the routine provision of HIV PrEP in community pharmacies in London

BMC Health Services Research
Background The United Kingdom’s (UK) integration of Pre-exposure Prophylaxis (PrEP) into community pharmacies presents an alternative avenue for supporting Human Immunodeficiency Virus (HIV) prevention.
Marsha Alter, Shivali Lakhani, Aos Alaa, Manisha Karki, Eva Riboli-Sasco, Austen El-Osta   +5 more
doaj   +1 more source

What is the interplay between self-care confidence, professional support and health literacy among UK adults? A cross-sectional online survey study

BMJ Open
Background The WHO defines self-care as ‘the ability of individuals, families and communities to promote health, prevent disease, maintain health and cope with illness and disability with or without the support of a healthcare provider’, while self-care ...
Peter Smith, Austen El-Osta, Sami Altalib, Mahmoud Al Ammouri   +3 more
doaj   +1 more source

Physician self-care

South African Medical Journal, 2014
Many of us have worked in the interminable queues of outpatient  departments. After a long day, we are greeted with the hopeful, tired faces of families with their ill loved ones. We are meant to be able to heal and cure. Yet, we often run out of options, treatments seem ineffective, and we have to hold the hands of those who are dying.
Kirby, J, Lück, P
openaire   +5 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Associations between knee extensor strength and gait characteristics derived from shoe-based wearable sensors in older women

Scientific Reports
Declining knee extensor strength (KES) is a recognized risk factor for musculoskeletal disorders including knee osteoarthritis. Regular self-assessment of knee extensor strength in older women is essential for prevention of the progression.
Takuma Inai, Shoma Kudo, Wakako Tsuchida, Masahiro Fujimoto   +3 more
doaj   +1 more source

A systematic review of adherence to diabetes self-care behaviours: evidence from low-and middle-income countries.

Journal of Advanced Nursing, 2019
AIMS To determine diabetes patient's adherence to five self-care behaviours (diet, exercise; medication, self-monitoring of blood glucose [SMBG] and foot care) in low- and middle-income countries DESIGN: Systematic review.
V. Mogre, N. Johnson, F. Tzelepis, J. Shaw, C. Paul   +4 more
semanticscholar   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Embedding work coaches in GP practices: Findings from an interview-based study in the UK

Public Health in Practice
Background: The integration of work coaches (WCs) and disability employment advisors (DEAs) into General Practitioner (GP) practices in the UK aims to address the interplay between health and employment by facilitating access to employment support ...
Shriti Pattani, Marie Line El Asmar, Manisha Karki, Eva Riboli Sasco, Lara Shemtob, Kabir Varghese, Austen El-Osta   +6 more
doaj   +1 more source

The effects of living environment on disaster workers: a one–year longitudinal study

BMC Psychiatry, 2016
Background Defense Force workers engaged in disaster relief activities might suffer from strong psychological stress due to the tasks that they had been involved.
Masanori Nagamine, Nahoko Harada, Jun Shigemura, Kosuke Dobashi, Makiko Yoshiga, Naoki Esaki, Miyuki Tanaka, Masaaki Tanichi, Aihide Yoshino, Kunio Shimizu   +9 more
doaj   +1 more source