Results 61 to 70 of about 11,204,895 (316)

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Public knowledge, self-management and advice-seeking for lower urinary tract symptoms and nocturia: findings from a national UK cross-sectional survey

BMJ Open
Objectives To determine the prevalence of lower urinary tract symptoms (LUTS) and nocturia, public knowledge of associated risk factors, self-management practices and advice-seeking behaviours among community-dwelling adults in the UK, as well as to ...
Jonathan Rees, Austen El-Osta, Marcus J Drake, Sami Altalib, Eva Riboli-Sasco   +4 more
doaj   +1 more source

Popular Diabetes Apps and the Impact of Diabetes App Use on Self-Care Behaviour: A Survey Among the Digital Community of Persons With Diabetes on Social Media

Frontiers in Endocrinology, 2019
Introduction: This study aimed to identify popular diabetes applications (apps) and to investigate the association of diabetes app use and other factors with cumulative self-care behaviour.
Mihiretu M Kebede, C. Pischke
semanticscholar   +1 more source

Self-care practices among type II diabetics in rural area of Kancheepuram district, Tamil Nadu

Journal of Family Medicine and Primary Care, 2020
Introduction: Type 2 diabetes mellitus is one of the most prevalent noncommunicable diseases in India. The acute and chronic complications of diabetes impact the physical, mental, and social well-being of the patients, thereby, placing a major burden on ...
R C Karthik, A. Radhakrishnan, A. Vikram, B. Arumugam, S. Jagadeesh   +4 more
semanticscholar   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Effect of Self-Management Program on Self-efficacy and Medication Adherence in Patients with Mechanical Heart Valve: a Randomized Clinical Trial [PDF]

Journal of Caring Sciences, 2019
Introduction: Patients with mechanical heart valve need anticoagulant therapy to prevent thrombotic events. The treatment interacts with some foods and drugs.
Leila Javan, Aanoshirvan Kazemnejad, Mahin Nomali, Maasumeh Zakerimoghadam   +3 more
doaj   +1 more source

The role of health literacy, depression, disease knowledge, and self-efficacy in self-care among adults with heart failure: An updated model.

Heart & lung : the journal of critical care, 2020
BACKGROUND Patients with inadequate health literacy and heart failure face high healthcare costs, more hospitalizations, and greater mortality. To address these negative consequences, patients need to improve heart failure self-care. Multiple factors may
Aleda M. H. Chen, K. Yehle, K. Plake, L. Rathman, J. Heinle, Robert T Frase, James G. Anderson, J. Bentley   +7 more
semanticscholar   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Investigating the potential accessibility to HIV pre-exposure prophylaxis via community pharmacies and sexual health clinics: a scoping review of two integrated care systems in London

BMC Health Services Research
Background Despite advancements in HIV prevention, barriers and disparities in accessing Pre-exposure Prophylaxis (PrEP) from specialist services persist.
Aos Alaa, Datapwa Mujong, Shivali Lakhani, Marsha Alter, Austen El-Osta   +4 more
doaj   +1 more source