Results 71 to 80 of about 5,151,261 (292)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

HUBUNGAN SELF EFFICACY DENGAN PERILAKU SELF CARE PASIEN PASCA STROKE DI RUMAH SAKIT ISLAM SURABAYA

Jurnal Ilmiah Kesehatan, 2018
The post-stroke can be regarded as the most difficult time for patients with post-stroke, they will experience a disability and inability to move as usual so that they will have difficulty in self care.
Ismatika Ismatika, Umdatus Soleha
doaj   +1 more source

How does gender influence the recognition of cardiovascular risk and adherence to self-care recommendations? : a study in polish primary care [PDF]

, 2013
Background: Studies have shown a correlation between gender and an ability to change lifestyle to reduce the risk of disease. However, the results of these studies are ambiguous, especially where a healthy lifestyle is concerned.
A Ellis, A Firkowska-Mankiewicz, A Ostrowska, AL Day, AR Opotowsky, B Tobiasz-Adamczyk, C Viswesvaran, CM Blanchard, CR Lopez, D Włodarczyk, DME Clark, DR McCreary, E Wojtyna, EH Oleksy, ER Greenglass, Ewa Wojtyna, F Babwah, FG Wood, HT Krajewski, I Bautista-Castaño, Ireneusz Szymczyk, J Fleury, J Rodin, JH Dwyer, Joanna Kępa, JT Ptacek, K Ahmad, KD Ward, KM King, L Gleiberman, L Malan, L Trudeau, LK Tamres, M Dabic, M Hamer, M Leinsalu, M Łopuszańska, MC Maultsby, MG Hunink, MR Azevedo, MR Law, MR Polen, MY Leung, NS Endler, NS Endler, P Szczepaniak, R Lazarus, R Ludwick-Rosenthal, RB Navuluri, RCP Kobiet, RL Brunner, RM Conroy, S Folkman, S Hobfoll, S Hobfoll, SCM Roberts, SL Lusk, SM Miller, SW Gibbons, Teresa Pawlikowska, U Goldbourt, U Schneider, Witold Lukas, WY Lim, Y Li, Z Juczyński, Z Spendel   +66 more
core   +2 more sources

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Spatiotemporal and kinematic gait characteristics in older patients with type 2 diabetes mellitus with and without sarcopenia

Scientific Reports
To investigate the differences in gait characteristics between older patients with type 2 diabetes with and without sarcopenia, using a three-dimensional motion analysis system.
Tomotaka Manabe, Wakako Tsuchida, Toshihiro Kobayashi, Masahiro Fujimoto, Takuma Inai, Kohei Kido, Shoma Kudo, Kensaku Fukunaga, Takanobu Saheki, Takafumi Yoshimura, Hitomi Imachi, Koji Murao   +11 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Administrator Satisfaction with Long-term Care Foodservice [PDF]

, 2011
This study investigated the satisfaction levels of Michigan long-term care administrators to determine whether they are more satisfied with self-operated or contract managed food service at their facility.
Ahern, Maria
core   +2 more sources

Developing a stoma acceptance questionnaire to improve motivation to adhere to enterostoma self-care [PDF]

, 2017
IntroductionIn stoma care, patient education is often weak in terms of improving patientsâ level of acceptance of living with a stoma. Self-care educational interventions in enterostomal patients, which according to Oremâs Theory should take into account
Aleo, Giuseppe, Bagnasco, Annamaria, Catania Gianluca, Sasso, Loredana, Watson, Roger, Zanini, Milko   +5 more
core   +2 more sources

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source