Results 91 to 100 of about 4,150,068 (295)

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Knowledge, beliefs and limitations on the use of orthodontic in Paraguay

Revista Facultad de Odontología Universidad de Antioquia
Introduction: Malocclusion is a significant oral health issue, with prevalence rates among children and adolescents ranging from 39% to 93%. The objective of this study was to describe the knowledge, beliefs, and limitations regarding the use of ...
Clarisse Díaz-Reissner, Cynthia Mireya Jara-Pintos, Cecilia Acosta-Garayo, Leticia Cataldi-López, Ana Kunzle-Correa   +4 more
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

IMPACT OF SELF ESTEEM & SUPPORT ON STUDENT PERFORMANCE [PDF]

Management & Marketing, 2012
Education is life blood for development of country. This paper explores the impact of various factors on student performance. Data was collected from ten (10) Govt. & Private schools in Rawalpindi.
Akmal SHAHZAD, Tanvir AHMED, Syed Ibne - Ali JAFFARI, Bashir Ahmed KHILJI   +3 more
doaj  

Natal Family Disruptions and Lives in Non-Parental Care:Impacts on Children’s Emotional Health and Academic Success [PDF]

, 2020
This research used a mixed methods design to evaluate the negative impacts of strains in children’s natal family environment, on their emotional and academic core self-concept, as well as how healthy non-parental relationships can help repair the damaged
Heid, Juliet
core   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Spatiotemporal brain dynamics of empathy for pain and happiness in friendship

Frontiers in Behavioral Neuroscience, 2016
Although a large number of fMRI studies have investigated the neural basis of empathy, little is known about its spatiotemporal dynamics. Moreover, most of the previous studies on empathy have focused on empathy for pain rather than empathy for positive ...
Wang eYi-Wen, Juan eSon, Fengbo eGuo, Zhen eZhang, Sheng eYuan, Stephanie eCacioppo   +5 more
doaj   +1 more source

The McCance Brain Care Score and Mortality: Evidence From a Large‐Scale Population‐Based Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives This study aimed to examine the relationship between the McCance Brain Care Score (BCS) and mortality in the general population. Methods We conducted a prospective, population‐based cohort study using data from the UK Biobank. Participants with complete data enabling calculation of BCS and full mortality information were included ...
Zhiqiang Xu, Xiaoxiao Wang, Nan Li
wiley   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source