Results 71 to 80 of about 12,458,695 (229)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Empowering Parents: The Impact of a Parenting Practice-Based Care Module on Preventing Internet Gaming Disorder in Elementary School Children

Iranian Journal of Nursing and Midwifery Research
Background: The prevalence of Internet Gaming Disorder (IGD) among elementary school children has raised concerns about its potential negative impact on academic performance, social interactions, and overall mental well-being.
Nur Hidaayah, Esti Yunitasari, Hanik Endang Nihayati   +2 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Gendered challenges faced by rural women self-help groups in Shurugwi District, Zimbabwe

The Dyke
This study explores the gendered challenges faced by rural women self-help groups in the Shurugwi District, Zimbabwe, and analyses how these challenges impact the sustainability of their projects. The absence of focused research on the specific gendered
Smart Mhembwe
doaj   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Women Empowerment through Self Help Groups: Case Study in Jalandhar District of Punjab

International Journal of Bio-Resource and Stress Management, 2017
Rural women today have been suffering a lot due to the feeling of helplessness and lack of decision-making capabilities in financial matters. Self-help groups (SHGs) are the most recent development for them which could enable them to come forward and ...
Lakhwinder Kaur, Divya Sachan, Arjun Sulibhavimath   +2 more
doaj  

Direct action self-help (DASH) groups in UK flood risk management

E3S Web of Conferences, 2016
This paper presents an analysis of the nature and effectiveness of community direct action self-help (DASH) groups and includes a case study analysis of a river conveyance management group and a sea wall management group.
Simm Jonathan
doaj   +1 more source