Results 161 to 170 of about 4,805 (202)
Responses to selinexor in multiple myeloma [PDF]
Nature Reviews Clinical Oncology, 2019 exaly +3 more sources
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Canadian Journal of Health Technologies, 2022
CADTH reimbursement reviews are comprehensive assessments of the clinical effectiveness and cost-effectiveness, as well as patient and clinician perspectives, of a drug or drug class. The assessments inform non-binding recommendations that help guide the reimbursement decisions of Canada's federal, provincial, and territorial governments ...
openaire +1 more source
CADTH reimbursement reviews are comprehensive assessments of the clinical effectiveness and cost-effectiveness, as well as patient and clinician perspectives, of a drug or drug class. The assessments inform non-binding recommendations that help guide the reimbursement decisions of Canada's federal, provincial, and territorial governments ...
openaire +1 more source
Selinexor for advanced hematologic malignancies
Leukemia & Lymphoma, 2020Recent measures to classify novel molecular targets with therapeutic potential across multiple hematologic tumors have identified the eukaryotic nuclear exporter, exportin 1 (XPO1), as a promising candidate. Molecular agents termed 'Selective Inhibitors of Nuclear Export' (SINEs) have been developed to selectively inhibit the essential regulatory ...
Janek S. Walker +2 more
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Selinexor: First Global Approval
Drugs, 2019Selinexor (XPOVIO™) is a first-in-class, oral, small molecule Exportin-1 (XPO1) inhibitor that is being developed by Karyopharm Therapeutics for the treatment of cancer. Selinexor (in combination with dexamethasone) received accelerated approval in the USA in July 2019 for the treatment of adult patients with relapsed or refractory multiple myeloma ...
exaly +3 more sources
The ‘comeback’ of Selinexor: From toxic to tolerable
Current Problems in Cancer, 2022Selinexor is a novel XPO1 inhibitor approved for patients with relapsed refractory multiple myeloma. When used as twice weekly dosing, selinexor is associated with significant toxicities, prohibiting its use in clinical practice. Newer combinations with other chemotherapeutic agents have evaluated less frequent and lower doses of Selinexor with ...
Hamza, Hashmi, Kimberly, Green
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Selinexor for the treatment of multiple myeloma
Expert Opinion on Pharmacotherapy, 2020Introduction: Despite unprecedented advances in the treatment of multiple myeloma (MM), almost all patients develop a disease that is resistant to the five most commonly used and active anti-MM agents. The prognosis for this patient population is particularly poor resulting in an unmet need for additional therapeutic options.
Klaus, Podar +4 more
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Selinexor in patients with advanced and recurrent endometrial cancer
Current Problems in Cancer, 2023Selinexor is an oral inhibitor of the nuclear export protein called Exportin 1 (XPO1) with demonstrated antitumor activity in hematological and solid tumors. Selinexor, blocking XPO1, induces nuclear localization of tumor suppressor proteins (including p53, p73, BRCA1, and pRB), leading to the selective induction of apoptosis, and inhibition of DNA ...
Giorgio, Bogani +9 more
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Expert Opinion on Pharmacotherapy
Selinexor, an XPO1 inhibitor, has emerged as a promising therapeutic option in the challenging landscape of relapsed/refractory multiple myeloma (RRMM).This article provides a review of selinexor, with a focus on available clinical studies involving MM patients and its safety profile.
Martino, Enrica Antonia +11 more
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Selinexor, an XPO1 inhibitor, has emerged as a promising therapeutic option in the challenging landscape of relapsed/refractory multiple myeloma (RRMM).This article provides a review of selinexor, with a focus on available clinical studies involving MM patients and its safety profile.
Martino, Enrica Antonia +11 more
openaire +2 more sources