Results 41 to 50 of about 2,851 (84)

Intermittent cocaine use patterns, not total intake, predict cue‐induced drug seeking in rats

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Cocaine‐associated cues trigger relapse to drug use in humans and animal models. In rats, long daily cocaine access (4–6 vs. 1–2 h) increases drug self‐administration and cue‐induced cocaine seeking, suggesting that greater intake promotes relapse.
Amélie Mainville‐Berthiaume, Hajer Algallal, Salomé Dupuis, Sema Abu Shamleh, Coralie Godbout, Vincent Jacquemet, Anne‐Noël Samaha   +6 more
wiley   +1 more source

GLP‐1‐Based Therapies in Type 1 Diabetes: Emerging Evidence on Cardiovascular, Renal, and Safety Outcomes

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Individuals living with type 1 diabetes (T1D) are at increased risk for cardiovascular (CV) and renal complications, yet therapeutic strategies specifically targeting cardiorenal risk reduction in this population remain limited. The role of glucagon‐like peptide‐1 (GLP‐1)‐based therapies in T1D remains unclear.
Anastasios Tentolouris, Djordje S. Popovic, Alexandros L. Liarakos, Alexandros Briasoulis, Nikolaos Papanas, Theocharis Koufakis   +5 more
wiley   +1 more source

SEMA: Deeply Learning Semantic Meanings and Temporal Dynamics for Recommendations

IEEE Access, 2018
Personalization plays an essential role in recommender systems, in which the key task is to predict the personalized rating of users on new items. Recommender systems usually apply collaborative filtering techniques to make rating prediction.
Jia-Dong Zhang, Chi-Yin Chow
doaj   +1 more source

Efficacy and Safety of Once‐Weekly Semaglutide 2.0 mg as an Add‐On to Dose‐Reduced Insulin Glargine versus Dose‐Titrated Insulin Glargine in People With Type 2 Diabetes and Overweight (SUSTAIN OPTIMIZE)

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Type 2 diabetes (T2D) management with basal insulin can lead to hypoglycaemia and weight gain. SUSTAIN OPTIMIZE compared once‐weekly semaglutide 2.0 mg as add‐on to dose‐reduced insulin glargine (Sema+IGlarreduced) versus dose‐titrated IGlar (IGlartitrated) on glycated haemoglobin (HbA1c), body weight (BW), daily insulin dose, and ...
Helena W. Rodbard, Concetta Irace, Jevitha Lobo, Konstantinos Makrilakis, Prachi Priyadarshini, Suvanjaa Sivalingam, Santiago Tofé Povedano, Anuj Bhargava   +7 more
wiley   +1 more source

Discovery of a Novel Variant of SEMA3A in a Chinese Patient with Isolated Hypogonadotropic Hypogonadism

International Journal of Endocrinology, 2021
Semaphorin (SEMA) has an important role in nerve development, organ formation, immune response, angiogenesis, and tumor growth. SEMA can regulate the growth and branching of axons, the morphology of dendrites, and the migration of neurons.
Wenting Dai, Jia-Da Li, Xinying Wang, Wang Zeng, Fang Jiang, Ruizhi Zheng   +5 more
doaj   +1 more source

Dens Invaginatus as a Biomechanical Risk Modifier in Dental Trauma: Finite Element Analysis

Dental Traumatology, EarlyView.
ABSTRACT Introduction/Aims Traumatic dental injuries are common in childhood and may adversely affect functional and psychosocial well‐being. Dens invaginatus, a developmental anomaly caused by the infolding of the enamel organ during odontogenesis, alters tooth morphology and may influence biomechanical behavior under traumatic loading.
Emine Şuranur Ayaz, Sema Aydınoğlu, Dilara Nil Günaçar, Ayberk Dizdar, Ecren Uzun Yaylaci, Murat Yaylaci, Mukaddes Yerebakan   +6 more
wiley   +1 more source

Enhanced Oral Efficacy of Semaglutide via an Ionic Nanocomplex with Organometallic Phyllosilicate in Type 2 Diabetic Rats

Pharmaceutics
This study aimed to develop an effective oral formulation of semaglutide, a glucagon-like peptide-1 receptor agonist, using an organometallic phyllosilicate-based colonic delivery system.
Gyu Lin Kim, Jae Geun Song, Hyo-Kyung Han   +2 more
doaj   +1 more source

Influence of Virtual Reality Haptic Simulators and Multi‐Layer Based Dental Preparation Plate on Skill Acquisition in Restorative Dentistry Preclinical Education

European Journal of Dental Education, EarlyView.
ABSTRACT Aim This study aimed to evaluate the effectiveness of virtual reality (VR) haptic simulators and a multi‐layered dental preparation plate (CaviPrep) in developing manual dexterity among third‐semester dental students during preclinical training in restorative dentistry.
Esra Yıldırım‐Manav, Sema Yazıcı‐Akbıyık, Sıla Nur Usta, Ayfer Ezgi Yılmaz‐Çakıroglu, Zeynep Bilge Kütük   +4 more
wiley   +1 more source

Medical Students' Perceptions of Peer‐Developed Video‐Based Training on Periodontal Health and Its Relationship With Systemic Diseases

European Journal of Dental Education, EarlyView.
ABSTRACT Introduction Periodontal health is an essential aspect of systemic health, with strong evidence linking it to diseases such as diabetes, cardiovascular diseases, and respiratory conditions. Despite these well‐documented connections, oral health remains underrepresented in medical education due to curriculum constraints.
Eda Tatlıcan, Erkin Erdoğan, Zeliha Aslı Öcek, Fahinur Ertuğrul, Sema Becerik   +4 more
wiley   +1 more source

Semaglutide in MASLD Patients: Improved Survival and Liver Outcomes

Pharmaceuticals
Introduction: Semaglutide (SEMA) has shown potential benefits in metabolic dysfunction-associated steatotic liver disease (MASLD). This large real-world study aimed to evaluate the effects of SEMA on MASLD patients’ clinical outcomes and liver-related ...
Mohamad Suki, Johnny Amer, Yael Milgrom, Muhammad Massarwa, Wadi Hazou, Yariv Tiram, Ofer Perzon, Yousra Sharif, Joseph Sackran, Revital Alon, Nachum Emil Eliezer Lourie, Itamar Raz, Ashraf Imam, Abed Khalaileh, Rifaat Safadi   +14 more
doaj   +1 more source