Results 41 to 50 of about 5,354,089 (273)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Redundancy Scheduling with Locally Stable Compatibility Graphs [PDF]
, 2020 Redundancy scheduling is a popular concept to improve performance in parallel-server systems. In the baseline scenario any job can be handled equally well by any server, and is replicated to a fixed number of servers selected uniformly at random.
Borst, Sem +2 more
core +2 more sources
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Potential of Thermal Energy Storage for a District Heating System Utilizing Industrial Waste Heat
Energies, 2020 The potential for utilizing industrial waste heat for district heating is enormous. There is, however, often a temporal mismatch between the waste heat availability and the heating demand, and typically fossil-based peak boilers are used to cover the ...
Hanne Kauko +3 more
doaj +1 more source
Cadernos de Campo (São Paulo - 1991), 2016 Este artigo busca fazer uma análise de um capítulo do romance de JorgeAmado Capitães da Areia à luz das teorias do parentesco. A situação criada naobra entre as personagens Sem-Pernas e Dona Ester suscita uma discussão sobreo papel da criança nas relações familiares e, mais especificamente, nas relaçõesde filiação.
openaire +2 more sources
Hyper-Scalable JSQ with Sparse Feedback
, 2019 Load balancing algorithms play a vital role in enhancing performance in data centers and cloud networks. Due to the massive size of these systems, scalability challenges, and especially the communication overhead associated with load balancing mechanisms,
Borst, Sem +2 more
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source