Results 121 to 130 of about 3,965,014 (302)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Effect of roasting on physicochemical, functional, thermal, pasting, and structural properties of tamarind seed powder

Food Chemistry Advances
The impact of different roasting conditions on the nutritional profile, physical, functional, thermal, pasting properties, morphology, crystallinity, and functional groups of tamarind seed powder (TSP) was investigated.
M Geethalaxmi, Ujjwal Kumar, Vijay Verma, C K Sunil, Ashish Rawson, N Venkatachalapathy   +5 more
doaj   +1 more source

Texture Feature Extraction and Classification of SEM Images of Wheat Straw/Polypropylene Composites in Accelerated Aging Test

Advances in Materials Science and Engineering, 2015
Wheat straw/polypropylene composites are green recycled and biomass-based material. After accelerated aging test of the composite was done, practical and effective methods for characterization and extraction of texture feature of microscopic Scanning ...
Huan Zhang, Chunxia He, Min Yu, Jingjing Fu   +3 more
doaj   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans

FEBS Open Bio, EarlyView.
In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller, Jana Bleher, Birgit Weinberger, Lourdes Rocamora‐Reverte   +3 more
wiley   +1 more source

teste sem mod secutity

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teste sem mod secutity, teste sem mod secutity
core  

NMR, FT-IR, XRD, SEM, and ANN Complex Characterization of Some Nonwoven Materials Produced by Electrospinning

Electrospinning is a versatile technique used to manufacture nanofibers by applying an electric field to a polymer solution. This method has gained significant interest in the biomedical, pharmaceutical, and materials engineering fields due to its ...
Florin Popa, Popa, Florin, Petru Pășcuță, Ramona Crainic, P\u103\u219cu\u21b\u103, Petru, Crainic, Ramona, Fechete, Radu, Radu Fechete   +7 more
core   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

SEM Characterization of Green Synthesized Nanoparticles

International Journal For Multidisciplinary Research
The present work covers the synthesis of six nanoparticles using a natural reducing agent obtained from tulsi (Ocimum sanctum) leaves. The method comprises boiling tulsi leaves in double distilled water and producing its juice which was used as the green reducing agent.
Syeda Zehra Musvi -, Swedha Hingnikar -, Dipti Patil -, Vaishnavi Karle -, Sanjay Harke -   +4 more
openaire   +1 more source

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M. Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Hardwick, Jonathan M. Yarimi, Nikita Shukla, Timothy E. Lotze, Kristen S. Fisher, Alexander J. Sandweiss   +13 more
wiley   +1 more source