Results 161 to 170 of about 9,266 (196)

Expression of semaphorin 3A, semaphorin 7A and their receptors in multiple sclerosis lesions

Multiple Sclerosis Journal, 2015
Background: Studies in multiple sclerosis (MS) and in experimental models point to a critical role of semaphorin (sema)3A and sema7A in MS pathogenesis. Objective: The objective of this paper is to characterise the expression of sema3A,
Cristina Costa, Xavier Montalbán, Carmen Espejo   +2 more
exaly   +3 more sources

The role of Semaphorin 3A in oral diseases

Oral Diseases, 2023
AbstractSemaphorin 3A (SEMA3A), also referred to as H‐Sema III, is a molecule with significant biological importance in regulating physiological and pathological processes. However, its role in oral diseases, particularly its association with inflammatory immunity and alveolar bone remodeling defects, remains poorly understood.
Xinyue Zhang, Zhenqi Yang, Demao Zhang, Mingru Bai   +3 more
openaire   +2 more sources

Osteoprotection by semaphorin 3A

Nature, 2012
The bony skeleton is maintained by local factors that regulate bone-forming osteoblasts and bone-resorbing osteoclasts, in addition to hormonal activity. Osteoprotegerin protects bone by inhibiting osteoclastic bone resorption, but no factor has yet been identified as a local determinant of bone mass that regulates both osteoclasts and osteoblasts ...
Mikihito, Hayashi, Tomoki, Nakashima, Masahiko, Taniguchi, Tatsuhiko, Kodama, Atsushi, Kumanogoh, Hiroshi, Takayanagi   +5 more
openaire   +2 more sources

Semaphorin 3A: an immunoregulator in systemic sclerosis

Rheumatology International, 2015
Semaphorin 3A (sema3A) plays a regulatory role in immune responses, mainly affecting the activation of regulatory T cells. It has been found to correlate with disease activity in rheumatoid arthritis and systemic lupus erythematosus (SLE). To investigate the expression of sema3A in patients with systemic sclerosis (SSc) compared to healthy controls and
Doron, Rimar, Yuval, Nov, Itzhak, Rosner, Gleb, Slobodin, Michael, Rozenbaum, Katy, Halasz, Tharwat, Haj, Nizar, Jiries, Lisa, Kaly, Nina, Boulman, Zahava, Vadasz   +10 more
openaire   +2 more sources

The Role Of Semaphorin 3A In The Skeletal System

Critical Reviews in Eukaryotic Gene Expression, 2015
Semaphorin 3A (Sema3A), characterized by a conserved N-terminal "Sema" domain, was originally described as an axon guidance molecule. Recent research indicates that it performs a critical function in the skeletal system. This review highlights recent advances in understanding of the role of Sema3A in the skeletal system as a regulator of bone ...
Peifu, Tang, Pengbin, Yin, Houchen, Lv, Licheng, Zhang, Lihai, Zhang   +4 more
openaire   +2 more sources

Localization of semaphorin 3A in the rat cornea

Experimental Eye Research, 2008
Semaphorin 3A (Sema3A) functions to guide the growth of neurons during development. We investigated the localization of Sema3A in the cornea, one of the most sensitive tissues in the body. Immunoblot analysis and reverse transcription-polymerase chain reaction analysis revealed that Sema3A protein and mRNA are expressed in the normal rat cornea ...
Naoyuki, Morishige, Ji-Ae, Ko, Yang, Liu, Tai-Ichiro, Chikama, Teruo, Nishida   +4 more
openaire   +2 more sources

The Responsiveness of Thymic Stromal Cells to semaphorin-3A

Immunological Investigations, 2020
The thymus is responsible for thymocyte differentiation into immunocompetent T lymphocytes. Different cell types in the thymic microenvironment actively cooperate in this process, interacting with the developing thymocytes through soluble factors, extracellular matrix (ECM) molecules, and receptors.
Marvin Paulo Lins, Návylla Candeia Medeiros, Julianderson Carmo, Felipe Lima Porto, Maria Danielma dos Santos Reis, Salete Smaniotto   +5 more
openaire   +2 more sources

Semaphorin 3A is a chemoattractant for cortical apical dendrites

Nature, 2000
The apical dendrites of pyramidal neurons integrate inputs from various cortical layers and are central to information processing. Here we show that the growth of apical dendrites towards the pial surface is regulated by a diffusible chemoattractant present at high levels near the marginal zone. A major component of this signal is semaphorin 3A (Sema3A)
F, Polleux, T, Morrow, A, Ghosh
openaire   +2 more sources

Semaphorin 3A expression in the colon of Hirschsprung disease

Birth Defects Research Part A: Clinical and Molecular Teratology, 2011
AbstractBACKGROUNDHirschsprung disease (HSCR) is a congenital disorder characterized by an absence of intrinsic ganglion cells in the nerve plexuses of the lower colon. The Semaphorin 3A (SEMA3A) gene is involved in the migration of enteric neural precursors (ENPs).
Li-Li, Wang, Yang, Fan, Feng-Hua, Zhou, Hui, Li, Yi, Zhang, Jia-Ning, Miao, Hui, Gu, Tian-Chu, Huang, Zheng-Wei, Yuan   +8 more
openaire   +2 more sources

Semaphorin-3A: a promising therapeutic tool in allergic rhinitis

Immunologic Research, 2022
Semaphorin-3A (Sema-3A), a secreted member of the semaphorin family, is well known for playing regulatory functions at all stages of the immune response. Sema-3A transduces signals by binding to its cognate receptors, namely, class A plexins (Plxns A1 to A4) and neuropilin-1 (Nrp-1).
Ramin Lotfi, Nahid Zamanimehr
openaire   +2 more sources