Role of Semaphorin 3A in Kidney Development and Diseases [PDF]
Diagnostics, 2023 Kidney diseases are worldwide public health problems affecting millions of people. However, there are still limited therapeutic options against kidney diseases. Semaphorin 3A (SEMA3A) is a secreted and membrane-associated protein, which regulates diverse
Yizhen Sang +5 more
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Semaphorin 3A: A potential target for prevention and treatment of nickel allergy [PDF]
Communications Biology, 2022 Semaphorin 3A is upregulated in keratinocytes upon nickel exposure, subsequently promoting Th1 cytokine responses and driving nickel allergic reactions.
Lipei Liu +4 more
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The effects of semaphorin 3A in bone and cartilage metabolism: fundamental mechanism and clinical potential [PDF]
Frontiers in Cell and Developmental Biology, 2023 Semaphorin 3A (Sema3A) is a neuroinformatic protein molecule with widespread expression across various tissues and organs. Recent investigations have unveiled its pivotal role in the skeletal system, primarily through its binding interactions with two co-
KaiLe Wu +11 more
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Semaphorin 3A—Glycosaminoglycans Interaction as Therapeutic Target for Axonal Regeneration [PDF]
Pharmaceuticals, 2021 Semaphorin 3A (Sema3A) is a cell-secreted protein that participates in the axonal guidance pathways. Sema3A acts as a canonical repulsive axon guidance molecule, inhibiting CNS regenerative axonal growth and propagation.
Yolanda Pérez +7 more
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Bioactive semaphorin 3A promotes sequential formation of sensory nerve and type H vessels during in situ osteogenesis [PDF]
Frontiers in Bioengineering and Biotechnology, 2023 Introduction: Sensory nerves and vessels are critical for skeletal development and regeneration, but crosstalk between neurovascular network and mineralization are not clear.
Xiaoxiao Han +8 more
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Semaphorin 3A regulates alveolar bone remodeling on orthodontic tooth movement [PDF]
Scientific Reports, 2022 Semaphorin 3A (Sema3A) promotes osteoblast differentiation and inhibits osteoclast differentiation. In the present study, we observed the regulation of alveolar bone remodeling by Sema3A during orthodontic tooth movement (OTM).
Hirokazu Kamei +2 more
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An increase in Semaphorin 3A biases the axonal direction and induces an aberrant dendritic arborization in an in vitro model of human neural progenitor differentiation [PDF]
Cell & Bioscience, 2022 Background Semaphorins (Sema) belong to a large family of repellent guidance cues instrumental in guiding axons during development. In particular, Class 3 Sema (Sema 3) is among the best characterized Sema family members and the only produced as secreted
Gabriella Ferretti +5 more
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Expression of semaphorin 3A (SEMA3A) in breast cancer subtypes [PDF]
Scientific ReportsBreast cancer is a major health concern, and its accurate diagnosis and management depend on identifying its histological type and biological subtype. Semaphorin-3A (SEMA3A) is a membrane protein with diverse roles in cellular processes, including cancer
Natalia Andryszak +6 more
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Induction of Semaphorin 3A by Resveratrol and Pinostilbene via Activation of the AHR-NRF2 Axis in Human Keratinocytes [PDF]
AntioxidantsSemaphorin 3A (SEMA3A), a nerve-repellent factor produced by keratinocytes, has an inhibitory effect on nerve extension to the epidermis. Epidermal innervation is involved in pruritus in inflammatory skin diseases such as atopic dermatitis (AD) and dry ...
Gaku Tsuji +4 more
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Lipid remodeling and circulating semaphorin 3A in diminished ovarian reserve [PDF]
Scientific ReportsDiminished ovarian reserve (DOR) lacks strong plasma biomarkers, and recent studies have implicated lipid remodeling in its pathophysiology. In our previous study, we noted elevated circulating levels of semaphorin 3A (SEMA3A) in women with DOR ...
S. Serafini +5 more
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