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Role of Semaphorin 3A in Kidney Development and Diseases [PDF]
Diagnostics, 2023 Kidney diseases are worldwide public health problems affecting millions of people. However, there are still limited therapeutic options against kidney diseases. Semaphorin 3A (SEMA3A) is a secreted and membrane-associated protein, which regulates diverse
Yizhen Sang +5 more
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Expression of semaphorin 3A (SEMA3A) in breast cancer subtypes [PDF]
Scientific Reports, 2023 Breast cancer is a major health concern, and its accurate diagnosis and management depend on identifying its histological type and biological subtype. Semaphorin-3A (SEMA3A) is a membrane protein with diverse roles in cellular processes, including cancer
Natalia Andryszak +6 more
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Semaphorin 3A: A potential target for prevention and treatment of nickel allergy [PDF]
Communications Biology, 2022 Semaphorin 3A is upregulated in keratinocytes upon nickel exposure, subsequently promoting Th1 cytokine responses and driving nickel allergic reactions.
Lipei Liu +4 more
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Semaphorin 3A in Ankylosing Spondylitis
Journal of Microbiology, Immunology and Infection, 2019 Background/Purpose: To determine serum semaphorin 3A (Sema 3A) levels in ankylosing spondylitis (AS). Methods: Serum Sema 3A was measured in 46 AS patients and 30 healthy controls (HCs).
Hsien-Tzung Liao +3 more
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The role of semaphorin 3A on chondrogenic differentiation. [PDF]
In Vitro Cell Dev Biol AnimAbstractOsteoblast-derived semaphorin3A (Sema3A) has been reported to be involved in bone protection, and Sema3A knockout mice have been reported to exhibit chondrodysplasia. From these reports, Sema3A is considered to be involved in chondrogenic differentiation and skeletal formation, but there are many unclear points about its function and mechanism ...
Tsuboi E +10 more
europepmc +3 more sources
The effects of semaphorin 3A in bone and cartilage metabolism: fundamental mechanism and clinical potential [PDF]
Frontiers in Cell and Developmental Biology, 2023 Semaphorin 3A (Sema3A) is a neuroinformatic protein molecule with widespread expression across various tissues and organs. Recent investigations have unveiled its pivotal role in the skeletal system, primarily through its binding interactions with two co-
KaiLe Wu +11 more
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Semaphorin‑3A alleviates cardiac hypertrophy by regulating autophagy. [PDF]
Exp Ther Med, 2023 Cardiac hypertrophy, characterized by cardiomyocyte enlargement, is an adaptive response of the heart to certain hypertrophic stimuli; however, prolonged hypertrophy results in cardiac dysfunction and can ultimately cause heart failure. The present study evaluated the role of semaphorin-3A (Sema3A), a neurochemical inhibitor, in cardiac hypertrophy ...
Sun Y +5 more
europepmc +3 more sources
Semaphorin 3A in the Immune System: Twenty Years of Study. [PDF]
Biochemistry (Mosc), 2022 Semaphorin 3A is a secreted glycoprotein, which was originally identified as axon guidance factor in the neuronal system, but it also possesses immunoregulatory properties. Here, the effect of semaphorin 3A on T-lymphocytes, myeloid dendritic cells and macrophages is systematically analyzed on the bases of all publications available in the literature ...
Kiseleva EP, Rutto KV.
europepmc +3 more sources
Semaphorin 3A, A Potential Target for Low Back Pain. [PDF]
Frontiers in Aging Neuroscience, 2015 Low back pain is a common disorder. Pathological innervation and intervertebral disc degeneration are two major factors associated with this disease. Semaphorin 3A, originally known for its potent inhibiting effect on axonal outgrowth, is recently found ...
Pengbin eYin +4 more
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Semaphorin 3A—Glycosaminoglycans Interaction as Therapeutic Target for Axonal Regeneration [PDF]
Pharmaceuticals, 2021 Semaphorin 3A (Sema3A) is a cell-secreted protein that participates in the axonal guidance pathways. Sema3A acts as a canonical repulsive axon guidance molecule, inhibiting CNS regenerative axonal growth and propagation.
Yolanda Pérez +7 more
doaj +2 more sources