The Role of Semaphorins in the Pathogenesis of Rheumatoid Arthritis [PDF]
CellsRheumatoid arthritis (RA) is one of the most common autoimmune diseases. Inflammation of the synovial fluid propagates the pathological process of angiogenesis.
Jakub Rosik +2 more
exaly +4 more sources
Semaphorins as Potential Immune Therapeutic Targets for Cancer
Frontiers in Oncology, 2022 Semaphorins are a large class of secreted or membrane-bound molecules. It has been reported that semaphorins play important roles in regulating several hallmarks of cancer, including angiogenesis, metastasis, and immune evasion.
Yi Wan
exaly +3 more sources
Semaphorins in Adult Nervous System Plasticity and Disease
Frontiers in Synaptic Neuroscience, 2021 Semaphorins, originally discovered as guidance cues for developing axons, are involved in many processes that shape the nervous system during development, from neuronal proliferation and migration to neuritogenesis and synapse formation.
Daniela Carulli +2 more
exaly +3 more sources
Semaphorins: from CD8⁺ T cells to cancer immunotherapy [PDF]
Biomarker ResearchSemaphorins were initially identified as axon guidance molecules in the nervous system, where they transmit repulsive signals to restrict axonal growth by regulating the dynamics of growth cone cytoskeletal structures.
Zhiying Liu +5 more
doaj +2 more sources
Serum Semaphorin Alterations in Psoriasis: Links to Metabolic Status Rather than Disease Severity [PDF]
MetabolitesIntroduction: Psoriasis is an autoimmune systemic disease of not entirely understood pathogenesis. It remains a significant therapeutic challenge and, due to its various comorbidities, has a remarkable detrimental effect on patients’ wellbeing ...
Anna Baran +6 more
doaj +2 more sources
Diverse Roles of Semaphorins on T Cell Activation, Differentiation, Migration, and Effector Functions [PDF]
CellsSemaphorins are a large family of proteins originally identified for their roles in axon guidance during neural development. Recent findings have established the importance of semaphorins members in modulating diverse immune responses of T cells in vitro
Heqing Ma +3 more
doaj +2 more sources
The Relationship Between Immune Semaphorins and Myasthenia Gravis [PDF]
Brain and BehaviorObjective Myasthenia gravis (MG) is an autoimmune disease involving several immune mechanisms. Recently, semaphorins have emerged as potential diagnostic and prognostic biomarkers in autoimmune neurological and non‐neurological diseases.
Dilcan Kotan +2 more
doaj +2 more sources
Neuropilin-1: A Multifaceted Target for Cancer Therapy [PDF]
Current OncologyNeuropilin-1 (NRP1), initially identified as a neuronal guidance protein, has emerged as a multifaceted regulator in cancer biology. Beyond its role in axonal guidance and angiogenesis, NRP1 is increasingly recognized for its significant impact on tumor ...
Sai Manasa Varanasi +4 more
doaj +2 more sources
An Outflow Tract Myocardium-Specific Enhancer at the Sema3c Locus During Heart Development. [PDF]
Genes CellsFocusing on an OFT‐specific differentially accessible region, in the present study, we defined a distal OFT myocardial enhancer whose activity depends on GATA binding sites. This enhancer provides insight into the mechanisms underlying spatially restricted Sema3c expression involved in OFT development.
Wang Y +5 more
europepmc +2 more sources
The Role of Immune Semaphorins in Sepsis—A Prospective Cohort Study [PDF]
MicroorganismsIn sepsis, a balanced pro-inflammatory and anti-inflammatory response results in the bacterial clearance and resolution of inflammation, promoting clinical recovery and survival.
Branimir Gjurasin +3 more
doaj +2 more sources