Plexins promote Hedgehog signaling through their cytoplasmic GAP activity [PDF]
eLife, 2022 Hedgehog signaling controls tissue patterning during embryonic and postnatal development and continues to play important roles throughout life. Characterizing the full complement of Hedgehog pathway components is essential to understanding its wide ...
Justine M Pinskey +7 more
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Semaphorin signaling restricts neuronal regeneration in C. elegans [PDF]
Frontiers in Cell and Developmental Biology, 2022 Extracellular signaling proteins serve as neuronal growth cone guidance molecules during development and are well positioned to be involved in neuronal regeneration and recovery from injury.
Maria B Harreguy +11 more
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Adult expression of Semaphorins and Plexins is essential for motor neuron survival [PDF]
Scientific Reports, 2023 Axon guidance cues direct the growth and steering of neuronal growth cones, thus guiding the axons to their targets during development. Nonetheless, after axons have reached their targets and established functional circuits, many mature neurons continue ...
Aarya Vaikakkara Chithran +2 more
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Semaphorins: from CD8⁺ T cells to cancer immunotherapy [PDF]
Biomarker ResearchSemaphorins were initially identified as axon guidance molecules in the nervous system, where they transmit repulsive signals to restrict axonal growth by regulating the dynamics of growth cone cytoskeletal structures.
Zhiying Liu +5 more
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Expression analysis and possible functional roles of semaphorin/plexin/CRMP families in mouse pancreatic islets [PDF]
Scientific ReportsSemaphorins were initially identified as axon guidance molecules that were widely expressed and involved in divergent functions in various organs, including neuronal development and immunological processes.
Mayu Kyohara +13 more
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Plexins as Regulators of Cancer Cell Proliferation, Migration, and Invasivity [PDF]
Cancers, 2023 Shira Toledano +2 more
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Participation of Semaphorin Family and Plexins in the Clinical Course of Patients with Inflammatory Bowel Disease [PDF]
International Journal of Molecular SciencesGabriela Fonseca-Camarillo +2 more
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Axon Guidance Molecules and Pain
Cells, 2022 Chronic pain is a debilitating condition that influences the social, economic, and psychological aspects of patients’ lives. Hence, the need for better treatment is drawing extensive interest from the research community.
Elisa Damo, Manuela Simonetti
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Semaphorin-3E/plexinD1 axis in allergic asthma
Advances in Biomedical and Health Sciences, 2022 Semaphorins are cell-membrane bound or secretory proteins that regulate cell migration, differentiation, proliferation, and morphology. Semaphorins are guidance cues that have either repulsive or attractive effects on growth cones and thus determine ...
Mojdeh Matloubi +4 more
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Analysis of the interaction of Plexin-B1 and Plexin-B2 with Rnd family proteins. [PDF]
PLoS ONE, 2017 The Rnd family of proteins, Rnd1, Rnd2 and Rnd3, are atypical Rho family GTPases, which bind to but do not hydrolyse GTP. They interact with plexins, which are receptors for semaphorins, and are hypothesised to regulate plexin signalling.
Thomas Wylie +3 more
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