Results 31 to 40 of about 2,365 (188)
Plexin-B2 negatively regulates macrophage motility, Rac, and Cdc42 activation. [PDF]
PLoS ONE, 2011 Plexins are cell surface receptors widely studied in the nervous system, where they mediate migration and morphogenesis though the Rho family of small GTPases.
Kelly E Roney +11 more
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SEMAPHORINS and their receptors: focus on the crosstalk between melanoma and hypoxia
Journal of Experimental & Clinical Cancer Research, 2021 Hypoxia, a condition of oxygen deprivation, is considered a hallmark of tumor microenvironment regulating several pathways and promoting cancer progression and resistance to therapy.
Elisabetta Valentini +3 more
doaj +1 more source
Frontiers in Immunology, 2021 Semaphorins are a group of proteins that have been studied extensively for their critical function in neuronal development. They have been shown to regulate airway development, tumorigenesis, autoimmune diseases, and the adaptive immune response. Notably,
Shreya M. Kanth +2 more
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Crystal structure of the Sema-PSI extracellular domain of human RON receptor tyrosine kinase. [PDF]
PLoS ONE, 2012 Human RON (Recepteur d'Origine Nantais) receptor tyrosine kinase is a cell surface receptor for Macrophage Stimulating Protein (MSP). RON mediates signal transduction pathways that regulate cell adhesion, invasion, motility and apoptosis processes ...
Kinlin L Chao +3 more
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Plexin-B1 and Plexin-B2 play non-redundant roles in GABAergic synapse formation
Molecular and Cellular Neuroscience, 2023 Abstract Synapse formation in the mammalian brain is a complex and dynamic process requiring coordinated function of dozens of molecular families such as cell adhesion molecules (CAMs) and ligand-receptor pairs (Ephs/Ephrins, Neuroligins/Neurexins, Semaphorins/Plexins).
Susannah S. Adel +6 more
openaire +3 more sources
Identification and characterization of a novel mouse plexin, plexin-A4
Mechanisms of Development, 2003 Plexins belonging to the plexin-A subfamily form complexes with neuropilins and propagate signals of class 3 semaphorins into neurons, even though they do not directly bind the semaphorins. In this study, we identified a new member of the plexin-A subfamily in the mice, plexin-A4, and showed that it was expressed in the developing nervous system with a
Suto, Fumikazu +4 more
openaire +2 more sources
Expression patterns of plexins and neuropilins are consistent with cooperative and separate functions during neural development. [PDF]
, 2006 BACKGROUND: Plexins are a family of transmembrane proteins that were shown to act as receptors for Semaphorins either alone or in a complex together with Neuropilins.
Stoeckli, E T; https://orcid.org/ +9 more
core +1 more source
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on PLXNB1 (plexin B1), with data on DNA, on the protein encoded, and where the gene is implicated.
Gómez-Román, JJ +3 more
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A perspective on the role of class III semaphorin signaling in central nervous system trauma
Frontiers in Cellular Neuroscience, 2014 Traumatic injury of the central nervous system (CNS) has severe impact on the patients’ quality of life and initiates many molecular and cellular changes at the site of insult.
Vasil eMecollari +3 more
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MICAL redox enzymes and actin remodeling: New links to classical tumorigenic and cancer pathways
Molecular & Cellular Oncology, 2018 MICAL Redox enzymes have recently emerged as direct regulators of cell shape and motility – working through specific reversible post-translational oxidation of actin to disassemble and remodel the cytoskeleton.
Jimok Yoon, Jonathan R. Terman
doaj +1 more source