Results 31 to 40 of about 2,043 (169)

Axon guidance molecules in immunometabolic diseases

Inflammation and Regeneration, 2022
The global prevalence of metabolic diseases, such as obesity, diabetes, and atherosclerosis, is rapidly increasing and has now reached epidemic proportions.
Yoshimitsu Nakanishi, Sujin Kang, Atsushi Kumanogoh   +2 more
doaj   +1 more source

A putative structural mechanism underlying the antithetic effect of homologous RND1 and RhoD GTPases in mammalian plexin regulation

eLife, 2021
Plexins are semaphorin receptors that play essential roles in mammalian neuronal axon guidance and in many other important mammalian biological processes.
Yanyan Liu, Pu Ke, Yi-Chun Kuo, Yuxiao Wang, Xuewu Zhang, Chen Song, Yibing Shan   +6 more
doaj   +1 more source

PLXNB1 (plexin B1) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on PLXNB1 (plexin B1), with data on DNA, on the protein encoded, and where the gene is implicated.
Gómez-Román, JJ, Nicolas, Martínez M, Lazuén, Fernández S, Val-Bernal, JF   +3 more
openaire   +2 more sources

Functional divergence of Plexin B structural motifs in distinct steps of Drosophila olfactory circuit assembly

eLife, 2019
Plexins exhibit multitudinous, evolutionarily conserved functions in neural development. How Plexins employ their diverse structural motifs in vivo to perform distinct roles is unclear. We previously reported that Plexin B (PlexB) controls multiple steps
Ricardo Guajardo, David J Luginbuhl, Shuo Han, Liqun Luo, Jiefu Li   +4 more
doaj   +1 more source

Structural Basis for Plexin Activation and Regulation [PDF]

Neuron, 2016
Class A plexins (PlxnAs) act as semaphorin receptors and control diverse aspects of nervous system development and plasticity, ranging from axon guidance and neuron migration to synaptic organization. PlxnA signaling requires cytoplasmic domain dimerization, but extracellular regulation and activation mechanisms remain unclear.
Kong, Youxin, Janssen, Bert J C, Malinauskas, Tomas, Vangoor, Vamshidhar R., Coles, Charlotte H., Kaufmann, Rainer, Ni, Tao, Gilbert, Robert J C, Padilla-Parra, Sergi, Pasterkamp, R. Jeroen, Jones, E. Yvonne   +10 more
openaire   +7 more sources

Recruitment of Tiam1 to Semaphorin 4D Activates Rac and Enhances Proliferation, Invasion, and Metastasis in Oral Squamous Cell Carcinoma

Neoplasia: An International Journal for Oncology Research, 2017
The semaphorins and the plexins are a family of large, cysteine-rich proteins originally identified as regulators of axon growth and lymphocyte activation that are now known to provide motility and positional information for a number of cell and tissue ...
Hua Zhou, Maricel G. Kann, Emily K. Mallory, Ying-Hua Yang, Amr Bugshan, Nada O. Binmadi, John R. Basile   +6 more
doaj   +1 more source

Genetic dissection of plexin signaling in vivo [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance Plexins, a family of transmembrane receptors for semaphorins, control diverse biological processes during mouse development. However, it is largely unknown through which signaling pathways they exert their functions in vivo.
Worzfeld, T., Swiercz, J., Senturk, A., Genz, B., Korostylev, A., Deng, S., Xia, J., Hoshino, M., Epstein, J., Chan, A., Vollmar, B., Acker-Palmer, A., Kuner, R., Offermanns, S.   +13 more
openaire   +3 more sources

Plexins function in epithelial repair in both Drosophila and zebrafish

Nature Communications, 2016
Plexins are semaphorin receptors and are well known for their roles in neuronal pathfinding. Here the authors describe a role for Plexin A in healing damaged epithelia in Drosophila and zebrafish. In Drosophila, Plexin A inhibits the GTPase Rap1 to allow
Sa Kan Yoo, Heath G. Pascoe, Telmo Pereira, Shu Kondo, Antonio Jacinto, Xuewu Zhang, Iswar K. Hariharan   +6 more
doaj   +1 more source

Perturbation of semaphorin and VEGF signaling in ACDMPV lungs due to FOXF1 deficiency

Respiratory Research, 2021
Background Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is a rare lethal congenital lung disorder in neonates characterized by severe progressive respiratory failure and refractory pulmonary hypertension, resulting from ...
Justyna A. Karolak, Tomasz Gambin, Przemyslaw Szafranski, Rebecca L. Maywald, Edwina Popek, Jason D. Heaney, Paweł Stankiewicz   +6 more
doaj   +1 more source

Structure of the Plexin Ectodomain Bound by Semaphorin-Mimicking Antibodies. [PDF]

PLoS ONE, 2016
Semaphorin family proteins act on cells to mediate both repulsive and attractive guidance via binding to plexin family receptors, thereby playing fundamental roles in the morphogenesis and homeostasis of various tissues.
Kei Suzuki, Hiroyuki Tsunoda, Ryusuke Omiya, Kyoko Matoba, Takeshi Baba, Sachiyo Suzuki, Hiroaki Segawa, Atsushi Kumanogoh, Kenji Iwasaki, Kunihiro Hattori, Junichi Takagi   +10 more
doaj   +1 more source