Analysis of the interaction of Plexin-B1 and Plexin-B2 with Rnd family proteins. [PDF]
PLoS ONE, 2017 The Rnd family of proteins, Rnd1, Rnd2 and Rnd3, are atypical Rho family GTPases, which bind to but do not hydrolyse GTP. They interact with plexins, which are receptors for semaphorins, and are hypothesised to regulate plexin signalling.
Thomas Wylie +3 more
doaj +7 more sources
Nationwide Survey of Atopic Myelitis and Plexin D1‐Immunoglobulin G‐Related Pain [PDF]
Annals of Clinical and Translational NeurologyObjective To elucidate the features of plexin D1‐immunoglobulin (Ig)G‐associated neuropathic pain and its relationship to atopic myelitis (AM) in a nationwide Japanese survey.
Jun‐ichi Kira +10 more
doaj +2 more sources
Plexin-B2 and Plexin-D1 in dendritic cells: expression and IL-12/IL-23p40 production. [PDF]
PLoS ONE, 2012 Plexins are a family of genes (A,B,C, and D) that are expressed in many organ systems. Plexins expressed in the immune system have been implicated in cell movement and cell-cell interaction during the course of an immune response.
Eda K Holl +8 more
doaj +5 more sources
Context-Dependent Dual Roles of the Plexin-B Family in Cancer Progression: Mechanisms and Therapeutic Implications [PDF]
Cancer Management and ResearchXiuli Mao,1,2,* Wenxian Lin,3,* Xiamin Zhang,1,2,* Mingyue Yang,4 Jiajia Shen,5 Huaqian Liang,6 Jian Song,2 Lingzhang Meng,2 Feng Long,7 Tonghua Wang,8,9 Yueyong Li10 1Graduate School, Youjiang Medical University for Nationalities,
Mao X +10 more
doaj +2 more sources
Plexin-B1 safeguards astrocyte agility and glial alignment to facilitate wound corralling and axon pathfinding in mouse spinal cord injury model [PDF]
Nature CommunicationsGlial spatial organization is critical for neural repair after spinal cord injury (SCI). In response to injury, reactive astrocytes extend hypertrophic processes to corral the lesion core and sequester debris and inflammatory cells.
Haofei Ni +8 more
doaj +2 more sources
Semaphorin 3E‐Plexin‐D1 Pathway Downstream of the Luteinizing Hormone Surge Regulates Ovulation, Granulosa Cell Luteinization, and Ovarian Angiogenesis in Mice [PDF]
Advanced ScienceOvulation is induced by the luteinizing hormone (LH) surge and accompanied by granulosa cell luteinization and ovarian angiogenesis. Semaphorin 3E (Sema3E)‐Plexin‐D1 pathway regulates angiogenesis in other tissues, but its role in the ovary is unknown ...
Hanxue Zhang +11 more
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Invasion of glioma cells through confined space requires membrane tension regulation and mechano-electrical coupling via Plexin-B2 [PDF]
Nature CommunicationsGlioblastoma (GBM) is a malignant brain tumor with diffuse infiltration. Here, we demonstrate how GBM cells usurp guidance receptor Plexin-B2 for confined migration through restricted space.
Chrystian Junqueira Alves +17 more
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Plexin-A2 enables the proliferation and the development of tumors from glioblastoma derived cells
Cell Death and Disease, 2023 The semaphorin guidance factors receptor plexin-A2 transduces sema6A and sema6B signals and may mediate, along with plexin-A4, the anti-angiogenic effects of sema6A.
Shira Toledano +5 more
doaj +1 more source
Structure of the Plexin Ectodomain Bound by Semaphorin-Mimicking Antibodies. [PDF]
PLoS ONE, 2016 Semaphorin family proteins act on cells to mediate both repulsive and attractive guidance via binding to plexin family receptors, thereby playing fundamental roles in the morphogenesis and homeostasis of various tissues.
Kei Suzuki +10 more
doaj +1 more source
Modeling transmembrane domain dimers/trimers of plexin receptors: implications for mechanisms of signal transmission across the membrane. [PDF]
PLoS ONE, 2015 Single-pass transmembrane (TM) receptors transmit signals across lipid bilayers by helix association or by configurational changes within preformed dimers. The structure determination for such TM regions is challenging and has mostly been accomplished by
Liqun Zhang +2 more
doaj +1 more source