Results 1 to 10 of about 6,523 (132)

Nationwide Survey of Atopic Myelitis and Plexin D1‐Immunoglobulin G‐Related Pain [PDF]

Annals of Clinical and Translational Neurology
Objective To elucidate the features of plexin D1‐immunoglobulin (Ig)G‐associated neuropathic pain and its relationship to atopic myelitis (AM) in a nationwide Japanese survey.
Jun‐ichi Kira, Xu Zhang, Takayuki Fujii, Mikio Mitsuishi, Miho Ushijima, Sato Yoshidomi, Ayako Sakoda, Tomohiro Imamura, Satoshi Kuwabara, Noriko Isobe, Yuri Nakamura   +10 more
doaj   +3 more sources

Context-Dependent Dual Roles of the Plexin-B Family in Cancer Progression: Mechanisms and Therapeutic Implications [PDF]

Cancer Management and Research
Xiuli Mao,1,2,* Wenxian Lin,3,* Xiamin Zhang,1,2,* Mingyue Yang,4 Jiajia Shen,5 Huaqian Liang,6 Jian Song,2 Lingzhang Meng,2 Feng Long,7 Tonghua Wang,8,9 Yueyong Li10 1Graduate School, Youjiang Medical University for Nationalities,
Mao X, Lin W, Zhang X, Yang M, Shen J, Liang H, Song J, Meng L, Long F, Wang T, Li Y   +10 more
doaj   +2 more sources

Soluble Sema4D From γδ T Cells Exerts Osteoblast Inhibition via Plexin-B/mTOR Signalling Contributing to Pathogenesis of Bisphosphonate-Related Osteonecrosis of the Jaws. [PDF]

Cell Prolif
Schematic summarizing the pathway of sSema4D from γδ T cells inhibiting osteoblast differentiation in BRONJ. ABSTRACT Bisphosphonate‐related osteonecrosis of the jaw (BRONJ) is a severe complication in patients undergoing long‐term bisphosphonate therapy, while our knowledge on the pathogenesis of BRONJ is far from sufficient.
Ou L, Qiao S, Liao Z, Tan X, Huang H, Zhou Z, Luo R, Zeng W, Yang Y, Zhang Z, Chen J, Wang S, Jiang Y, Hao J, Shen Y, Shao L.   +15 more
europepmc   +2 more sources

Semaphorin 3E‐Plexin‐D1 Pathway Downstream of the Luteinizing Hormone Surge Regulates Ovulation, Granulosa Cell Luteinization, and Ovarian Angiogenesis in Mice [PDF]

Advanced Science
Ovulation is induced by the luteinizing hormone (LH) surge and accompanied by granulosa cell luteinization and ovarian angiogenesis. Semaphorin 3E (Sema3E)‐Plexin‐D1 pathway regulates angiogenesis in other tissues, but its role in the ovary is unknown ...
Hanxue Zhang, Jimmy Dhillon, Paul D. Soloway, Bo Shui, Seoyeon Lee, Jennifer K. Grenier, Paul R. Munn, M. Cecilia Ljungberg, Rebecca B Williams, Rainer B. Lanz, Yu‐Hsiang Liao, Yi A. Ren   +11 more
doaj   +2 more sources

Plexin-B1 safeguards astrocyte agility and glial alignment to facilitate wound corralling and axon pathfinding in mouse spinal cord injury model [PDF]

Nature Communications
Glial spatial organization is critical for neural repair after spinal cord injury (SCI). In response to injury, reactive astrocytes extend hypertrophic processes to corral the lesion core and sequester debris and inflammatory cells.
Haofei Ni, Zhilai Zhou, Molly Estill, Dalia Halawani, Chrystian Junqueira Alves, Li Shen, Ning Xie, Roland H. Friedel, Hongyan Zou   +8 more
doaj   +2 more sources

Invasion of glioma cells through confined space requires membrane tension regulation and mechano-electrical coupling via Plexin-B2 [PDF]

Nature Communications
Glioblastoma (GBM) is a malignant brain tumor with diffuse infiltration. Here, we demonstrate how GBM cells usurp guidance receptor Plexin-B2 for confined migration through restricted space.
Chrystian Junqueira Alves, Theodore Hannah, Sita Sadia, Christy Kolsteeg, Angela Dixon, Robert J. Wiener, Ha Nguyen, Murray J. Tipping, Júlia Silva Ladeira, Paula Fernandes da Costa Franklin, Nathália de Paula Dutra de Nigro, Rodrigo Alves Dias, Priscila V. Zabala Capriles, José P. Rodrigues Furtado de Mendonça, Paul A. Slesinger, Kevin D. Costa, Hongyan Zou, Roland H. Friedel   +17 more
doaj   +2 more sources

Plexin-B2 and Plexin-D1 in dendritic cells: expression and IL-12/IL-23p40 production. [PDF]

PLoS ONE, 2012
Plexins are a family of genes (A,B,C, and D) that are expressed in many organ systems. Plexins expressed in the immune system have been implicated in cell movement and cell-cell interaction during the course of an immune response.
Eda K Holl, Kelly E Roney, Irving C Allen, Erin Steinbach, Janelle C Arthur, Adam Buntzman, Scott Plevy, Jeffrey Frelinger, Jenny P-Y Ting   +8 more
doaj   +1 more source

Analysis of the interaction of Plexin-B1 and Plexin-B2 with Rnd family proteins. [PDF]

PLoS ONE, 2017
The Rnd family of proteins, Rnd1, Rnd2 and Rnd3, are atypical Rho family GTPases, which bind to but do not hydrolyse GTP. They interact with plexins, which are receptors for semaphorins, and are hypothesised to regulate plexin signalling.
Thomas Wylie, Ritu Garg, Anne J Ridley, Maria R Conte   +3 more
doaj   +1 more source

Plexin-A2 enables the proliferation and the development of tumors from glioblastoma derived cells

Cell Death and Disease, 2023
The semaphorin guidance factors receptor plexin-A2 transduces sema6A and sema6B signals and may mediate, along with plexin-A4, the anti-angiogenic effects of sema6A.
Shira Toledano, Adi D. Sabag, Neta Ilan, Tanya Liburkin-Dan, Ofra Kessler, Gera Neufeld   +5 more
doaj   +1 more source

Structure of the Plexin Ectodomain Bound by Semaphorin-Mimicking Antibodies. [PDF]

PLoS ONE, 2016
Semaphorin family proteins act on cells to mediate both repulsive and attractive guidance via binding to plexin family receptors, thereby playing fundamental roles in the morphogenesis and homeostasis of various tissues.
Kei Suzuki, Hiroyuki Tsunoda, Ryusuke Omiya, Kyoko Matoba, Takeshi Baba, Sachiyo Suzuki, Hiroaki Segawa, Atsushi Kumanogoh, Kenji Iwasaki, Kunihiro Hattori, Junichi Takagi   +10 more
doaj   +1 more source