Results 31 to 40 of about 6,576 (169)
Downregulation of Endothelial Plexin A4 Under Inflammatory Conditions Impairs Vascular Integrity
Frontiers in Cardiovascular Medicine, 2021 Objective: Besides hyperlipidemia, inflammation is an important determinant in the initiation and the progression of atherosclerosis. As Neuroimmune Guidance Cues (NGCs) are emerging as regulators of atherosclerosis, we set out to investigate the ...
Dianne Vreeken +10 more
doaj +1 more source
Frontiers in Immunology, 2021 Semaphorins are a group of proteins that have been studied extensively for their critical function in neuronal development. They have been shown to regulate airway development, tumorigenesis, autoimmune diseases, and the adaptive immune response. Notably,
Shreya M. Kanth +2 more
doaj +1 more source
Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics
Communications Biology, 2021 Huang et al demonstrate that glioblastoma cells upregulate axon guidance molecule Plexin-B2 to gain invasiveness and that Plexin-B2 promotes glioblastoma cell infiltration along axon fiber tracts in intracranial transplant models by modulating cellular ...
Yong Huang +14 more
doaj +1 more source
Genetic dissection of plexin signaling in vivo [PDF]
Proceedings of the National Academy of Sciences, 2014 Significance Plexins, a family of transmembrane receptors for semaphorins, control diverse biological processes during mouse development. However, it is largely unknown through which signaling pathways they exert their functions in vivo.
Worzfeld, T. +13 more
openaire +3 more sources
Plexins promote Hedgehog signaling through their cytoplasmic GAP activity
eLife, 2022 Hedgehog signaling controls tissue patterning during embryonic and postnatal development and continues to play important roles throughout life. Characterizing the full complement of Hedgehog pathway components is essential to understanding its wide ...
Justine M Pinskey +7 more
doaj +1 more source
PlexinA1 Autoinhibition by the Plexin Sema Domain [PDF]
Neuron, 2001 Semaphorin 3A (Sema3A) binds to neuropilin-1 (NP1) and activates the transmembrane Plexin to transduce a repulsive axon guidance signal. Here, we show that Sema3 signals are transduced equally effectively by PlexinA1 or PlexinA2, but not by PlexinA3.
Takahashi, Takuya +1 more
openaire +2 more sources
Neurobiology of Disease, 2023 Background: Olfactory ensheathing cells (OECs) serve as a bridge by migrating at the site of spinal cord injury (SCI) to facilitate the repair of the neural structure and neural function.
MinChao Zhao +10 more
doaj +1 more source
Plexin-B1 mutations in prostate cancer [PDF]
Proceedings of the National Academy of Sciences, 2007 Semaphorins are a large class of secreted or membrane-associated proteins that act as chemotactic cues for cell movement via their transmembrane receptors, plexins. We hypothesized that the function of the semaphorin signaling pathway in the control of cell migration could be harnessed by cancer cells during invasion and metastasis.
Oscar Gee-Wan, Wong +17 more
openaire +2 more sources
eLife, 2013 Plexins are cell surface receptors that bind semaphorins and transduce signals for regulating neuronal axon guidance and other processes. Plexin signaling depends on their cytoplasmic GTPase activating protein (GAP) domain, which specifically inactivates
Yuxiao Wang +4 more
doaj +1 more source
Deconstruction of Human Age‐Related Cataract Capsules Defines Aging
Advanced Science, EarlyView.We generate a comprehensive atlas of age‐related cataracts (ARC) at a single‐cell resolution, encompassing three disease states—mild cataract group (Mild), severe cortical cataract group (Severe_C), and severe nuclear cataract group (Severe_N). We find that ARC involves seven distinct lens capsule cell types, with notable differences in cellular ...
Qiaomei Tang +9 more
wiley +1 more source