Results 31 to 40 of about 7,658 (197)
Plexin D1 is ubiquitously expressed on tumor vessels and tumor cells in solid malignancies
BMC Cancer, 2009 Background Plexin D1 is expressed on both tumor-associated endothelium and malignant cells in a number of clinical brain tumors. Recently we demonstrated that Plexin D1 expression is correlated with tumor invasion level and metastasis in a human melanoma
Raats Jos +3 more
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Structural Basis for Plexin Activation and Regulation [PDF]
Neuron, 2016 Class A plexins (PlxnAs) act as semaphorin receptors and control diverse aspects of nervous system development and plasticity, ranging from axon guidance and neuron migration to synaptic organization. PlxnA signaling requires cytoplasmic domain dimerization, but extracellular regulation and activation mechanisms remain unclear.
Kong, Youxin +10 more
openaire +7 more sources
eLife, 2021 Plexins are semaphorin receptors that play essential roles in mammalian neuronal axon guidance and in many other important mammalian biological processes.
Yanyan Liu +6 more
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The plexin-B family and its role in cancer progression [PDF]
, 2014 Plexins are transmembrane protein receptors for semaphorin molecules. These molecules are involved in numerous cellular activities related to cell proliferation, adhesion along with the basement membrane, cellular motility and invasive capability.
Malik, Muhammad Faraz A. +4 more
core +1 more source
Semaphorin-4D (Sema-4D), the Plexin-B1 ligand, is involved in mouse ovary follicular development
Reproductive Biology and Endocrinology, 2007 Background Human Plexin-B1 is expressed in two truncated forms. The long form encodes a trans-membranal protein, while the short form, which is bound to the cell surface and partially secreted, possibly serves as a decoy receptor.
Goldman Shlomit +2 more
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eLife, 2014 Deleting a gene called Sema5A, which has been linked to autism in humans, causes neurons to form more connections in mice, and also alters how these mutant mice interact with other mice.
Justin W Kenney, Paul W Frankland
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Stepwise wiring of the Drosophila olfactory map requires specific Plexin B levels
eLife, 2018 The precise assembly of a neural circuit involves many consecutive steps. The conflict between a limited number of wiring molecules and the complexity of the neural network impels each molecule to execute multiple functions at different steps.
Jiefu Li +8 more
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Mechanochemical control of epidermal stem cell divisions by B-plexins
Nature Communications, 2021 It is unclear how epithelial tissues adjust cell division rates to cell density. Here, the authors show that Plexin-B1 and Plexin-B2 sense mechanical compression (crowding) of epidermal stem cells, resulting in inactivation of YAP and suppression of cell
Chen Jiang +21 more
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Plexins promote Hedgehog signaling through their cytoplasmic GAP activity
eLife, 2022 Hedgehog signaling controls tissue patterning during embryonic and postnatal development and continues to play important roles throughout life. Characterizing the full complement of Hedgehog pathway components is essential to understanding its wide ...
Justine M Pinskey +7 more
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Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics
Communications Biology, 2021 Huang et al demonstrate that glioblastoma cells upregulate axon guidance molecule Plexin-B2 to gain invasiveness and that Plexin-B2 promotes glioblastoma cell infiltration along axon fiber tracts in intracranial transplant models by modulating cellular ...
Yong Huang +14 more
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