Results 21 to 30 of about 6,576 (169)
Plexin D1 is ubiquitously expressed on tumor vessels and tumor cells in solid malignancies
BMC Cancer, 2009 Background Plexin D1 is expressed on both tumor-associated endothelium and malignant cells in a number of clinical brain tumors. Recently we demonstrated that Plexin D1 expression is correlated with tumor invasion level and metastasis in a human melanoma
Raats Jos +3 more
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Plexin-B1 and Plexin-B2 play non-redundant roles in GABAergic synapse formation
Molecular and Cellular Neuroscience, 2023 Abstract Synapse formation in the mammalian brain is a complex and dynamic process requiring coordinated function of dozens of molecular families such as cell adhesion molecules (CAMs) and ligand-receptor pairs (Ephs/Ephrins, Neuroligins/Neurexins, Semaphorins/Plexins).
Susannah S. Adel +6 more
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eLife, 2021 Plexins are semaphorin receptors that play essential roles in mammalian neuronal axon guidance and in many other important mammalian biological processes.
Yanyan Liu +6 more
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Canadian Journal of Gastroenterology and Hepatology, 2018 Background and Aims. Hepatocellular carcinoma is an aggressive malignancy of the liver and is ranked as the sixth most common cancer worldwide. There is still room for novel markers to improve the diagnosis and monitoring of HCC.
Gorkem Odabas +5 more
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Semaphorin-4D (Sema-4D), the Plexin-B1 ligand, is involved in mouse ovary follicular development
Reproductive Biology and Endocrinology, 2007 Background Human Plexin-B1 is expressed in two truncated forms. The long form encodes a trans-membranal protein, while the short form, which is bound to the cell surface and partially secreted, possibly serves as a decoy receptor.
Goldman Shlomit +2 more
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Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on PLXNB1 (plexin B1), with data on DNA, on the protein encoded, and where the gene is implicated.
Gómez-Román, JJ +3 more
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eLife, 2014 Deleting a gene called Sema5A, which has been linked to autism in humans, causes neurons to form more connections in mice, and also alters how these mutant mice interact with other mice.
Justin W Kenney, Paul W Frankland
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Structural Basis for Plexin Activation and Regulation [PDF]
Neuron, 2016 Class A plexins (PlxnAs) act as semaphorin receptors and control diverse aspects of nervous system development and plasticity, ranging from axon guidance and neuron migration to synaptic organization. PlxnA signaling requires cytoplasmic domain dimerization, but extracellular regulation and activation mechanisms remain unclear.
Kong, Youxin +10 more
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Stepwise wiring of the Drosophila olfactory map requires specific Plexin B levels
eLife, 2018 The precise assembly of a neural circuit involves many consecutive steps. The conflict between a limited number of wiring molecules and the complexity of the neural network impels each molecule to execute multiple functions at different steps.
Jiefu Li +8 more
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Mechanochemical control of epidermal stem cell divisions by B-plexins
Nature Communications, 2021 It is unclear how epithelial tissues adjust cell division rates to cell density. Here, the authors show that Plexin-B1 and Plexin-B2 sense mechanical compression (crowding) of epidermal stem cells, resulting in inactivation of YAP and suppression of cell
Chen Jiang +21 more
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