Results 41 to 50 of about 7,658 (197)

PlexinA1 Autoinhibition by the Plexin Sema Domain [PDF]

Neuron, 2001
Semaphorin 3A (Sema3A) binds to neuropilin-1 (NP1) and activates the transmembrane Plexin to transduce a repulsive axon guidance signal. Here, we show that Sema3 signals are transduced equally effectively by PlexinA1 or PlexinA2, but not by PlexinA3.
Takahashi, Takuya, Strittmatter, Stephen M   +1 more
openaire   +2 more sources

Downregulation of Endothelial Plexin A4 Under Inflammatory Conditions Impairs Vascular Integrity

Frontiers in Cardiovascular Medicine, 2021
Objective: Besides hyperlipidemia, inflammation is an important determinant in the initiation and the progression of atherosclerosis. As Neuroimmune Guidance Cues (NGCs) are emerging as regulators of atherosclerosis, we set out to investigate the ...
Dianne Vreeken, Caroline Suzanne Bruikman, Wendy Stam, Stefan Martinus Leonardus Cox, Zsófia Nagy, Huayu Zhang, Rudmer Johannes Postma, Anton Jan van Zonneveld, Gerard Kornelis Hovingh, Gerard Kornelis Hovingh, Janine Maria van Gils   +10 more
doaj   +1 more source

Plexin-B1 mutations in prostate cancer [PDF]

Proceedings of the National Academy of Sciences, 2007
Semaphorins are a large class of secreted or membrane-associated proteins that act as chemotactic cues for cell movement via their transmembrane receptors, plexins. We hypothesized that the function of the semaphorin signaling pathway in the control of cell migration could be harnessed by cancer cells during invasion and metastasis.
Oscar Gee-Wan, Wong, Tharani, Nitkunan, Izumi, Oinuma, Chun, Zhou, Veronique, Blanc, Richard S D, Brown, Simon R J, Bott, Joseph, Nariculam, Gary, Box, Phillipa, Munson, Jason, Constantinou, Mark R, Feneley, Helmut, Klocker, Suzanne A, Eccles, Manabu, Negishi, Alex, Freeman, John R, Masters, Magali, Williamson   +17 more
openaire   +2 more sources

The Role of Semaphorins and Their Receptors in Innate Immune Responses and Clinical Diseases of Acute Inflammation

Frontiers in Immunology, 2021
Semaphorins are a group of proteins that have been studied extensively for their critical function in neuronal development. They have been shown to regulate airway development, tumorigenesis, autoimmune diseases, and the adaptive immune response. Notably,
Shreya M. Kanth, Salina Gairhe, Parizad Torabi-Parizi   +2 more
doaj   +1 more source

miR-145a-5p/Plexin-A2 promotes the migration of OECs and transplantation of miR-145a-5p engineered OECs enhances the functional recovery in rats with SCI

Neurobiology of Disease, 2023
Background: Olfactory ensheathing cells (OECs) serve as a bridge by migrating at the site of spinal cord injury (SCI) to facilitate the repair of the neural structure and neural function.
MinChao Zhao, Jiaxi Li, Zhengchao Gao, Dong Guo, Yubing Yang, Fang Wang, Lumin Wang, Yang Yang, Xijing He, Haopeng Li, Su’e Chang   +10 more
doaj   +1 more source

Structural basis for activation and non-canonical catalysis of the Rap GTPase activating protein domain of plexin

eLife, 2013
Plexins are cell surface receptors that bind semaphorins and transduce signals for regulating neuronal axon guidance and other processes. Plexin signaling depends on their cytoplasmic GTPase activating protein (GAP) domain, which specifically inactivates
Yuxiao Wang, Heath G Pascoe, Chad A Brautigam, Huawei He, Xuewu Zhang   +4 more
doaj   +1 more source

c‐Met‐Targeted Imaging Agents: Progress and Challenges

iRADIOLOGY, EarlyView.
This review summarizes recent advances in c‐Met‐targeted imaging probes, including hepatocyte growth factor (HGF) ligands, antibodies, peptides, and small molecules across magnetic resonance imaging (MRI), positron emission tomography (PET), single‐photon emission computed tomography (SPECT), and optical imaging modalities.
Yonghao Li, Aiyan Ji, Qihang Ding, Hongyue Lou, Zhen Cheng   +4 more
wiley   +1 more source

Comparison of the efficacy of combined budesonide and fexofenadine versus combined fluticasone propionate and fexofenadine on the expression of class-4 semaphorins and their receptors in the peripheral blood cells of patients with allergic rhinitis

Heliyon
Background: Allergic rhinitis (AR) is a common immunoglobulin (Ig) E-mediated disease. This study aimed to evaluate the gene expression levels of class 4 semaphorins and their receptors in AR patients before and after treatment with budesonide and ...
Gelayol Asadi, Parisa Feizollahi, Misagh Rajabinejad, Sara Falahi, Fatemeh Rezaei Varmaziar, Elham Faryadi, Ali Gorgin Karaji, Farhad Salari, Alireza Rezaiemanesh   +8 more
doaj   +1 more source

Semaphorin-Plexin signaling influences early ventral telencephalic development and thalamocortical axon guidance

Neural Development, 2017
Background Sensory processing relies on projections from the thalamus to the neocortex being established during development. Information from different sensory modalities reaching the thalamus is segregated into specialized nuclei, whose neurons then ...
Manuela D. Mitsogiannis, Graham E. Little, Kevin J. Mitchell   +2 more
doaj   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source