Results 61 to 70 of about 7,658 (197)

Spatial transcriptomics reveals a new cluster of fibroblasts to promote the progression of lung adenocarcinoma

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
1. Spatial transcriptomics reveals two types of colocation patterns between lung cancer cells and fibroblasts in LUAD. SPP1+ TM4SF4+ epithelial cells and COL+ fibroblasts were co‐located in a highly malignant region, while SFTPC+ epithelial cells and DCN+ fibroblasts were in a low malignant region. 2.
Liyang Li, Xiaoxia Liu, Yifei Liu, Xuanqi Liu, Wanxin Duan, Yujia Jiang, Jian Chen, Tianxiang Chen, Gang Chen, Ao Chen, Duojiao Wu, Dongli Song, Yuanlin Song   +12 more
wiley   +1 more source

Epigenetic Aging in Brain Tissue of the Self‐Fertilizing Vertebrate, Kryptolebias marmoratus

Ecology and Evolution, Volume 16, Issue 6, June 2026.
Using the self‐fertilizing vertebrate Kryptolebias marmoratus, we developed an epigenetic clock from brain tissue that predicts chronological age with high accuracy, demonstrating that DNA methylation changes consistently with age even in the near absence of genetic variation. The 40 age‐associated CpG sites identified map to genes with conserved roles
Justine Bélik, Frédéric Silvestre
wiley   +1 more source

Aspartame Increases the Risk of Pancreatic Ductal Adenocarcinoma

eFood, Volume 7, Issue 3, June 2026.
Aspartame (APM) is a widely used artificial sweetener associated with various health concerns, including potential links to diabetes, cardiovascular diseases, and an increased risk of cancer. A comprehensive approach incorporating data mining, machine learning, network toxicology, molecular docking, molecular dynamics simulations, and clinical sample ...
Jumin Xie, Wei Fang, Zean Song, Zhang Yu, Ying Zhu, Shaoping Liu   +5 more
wiley   +1 more source

Plexin A3 and plexin A4 convey semaphorin signals during facial nerve development

Developmental Biology, 2008
In vertebrates, class 3 semaphorins (SEMA3) control axon behaviour by binding to neuronal cell surface receptors composed of a ligand binding subunit termed neuropilin (NRP) and a signal transduction subunit of the A-type plexin family (PLXNA). We have determined the requirement for SEMA3/NRP/PLXN signalling in the development of the facial nerve ...
Schwarz, Quenten, Waimey, Kathryn E., Golding, Matthew, Takamatsu, Hyota, Kumanogoh, Atsushi, Fujisawa, Hajime, Cheng, Hwai-Jong, Ruhrberg, Christiana   +7 more
openaire   +2 more sources

Depletion of microglial compensation in glial network: Disease‐associated response dynamics in the revised amyloid hypothesis

Neuroprotection, Volume 4, Issue 2, Page 131-142, June 2026.
The critical transition from amyloid pathology to irreversible neuronal loss in Alzheimer's disease hinges on the microglial response. This review aims to systematize the patterns of how microglia react within the glial context. Abstract Microglia mount coordinated, stage‐dependent compensatory programs in response to early amyloid β (Aβ) accumulation ...
Songtao Lei, Zixuan Huang, Wen Wang, Yan Meng   +3 more
wiley   +1 more source

Biochemical bone biomarkers in plasma cell dyscrasias

British Journal of Haematology, Volume 208, Issue 6, Page 1909-1923, June 2026.
Visual abstract depicting that bone turnover markers reflect dynamic alterations in bone remodelling across the spectrum of plasma cell dyscrasias but remain limited by assay variability, biological confounding and incomplete integration with imaging and risk stratification.
Guido Nador, Rohit Vijjhalwar, Muhammad Kassim Javaid, Claire M. Edwards, Karthik Ramasamy   +4 more
wiley   +1 more source

Serum Levels of Plexin B2 in Psoriasis: A case-control study

SVU - International Journal of Medical Sciences
Background: Psoriasis is a severe, long-lasting, immune-mediated, hyperproliferative, and inflammatory skin condition that can cause painful or itchy lesions and have a significant impact on quality of life.
Eisa M. Hegazy , Moustafa A El- Taieb , Mohammed Hassan , Ebtehal A El-Din , Hassan M. Ibrahim   +4 more
doaj   +1 more source

Microglia Mitochondria Support Neuronal Maturation via Metabolic and Transcriptional Reprogramming in Human 3D In Vitro Brain Model

Advanced Science, Volume 13, Issue 25, 4 May 2026.
xx xx. ABSTRACT Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by disrupted neuronal circuit maturation. Emerging evidence implicates microglial function and mitochondrial regulation as contributors to ASD‐associated biology, yet the mechanisms linking these processes to neuronal development remain poorly defined ...
Sydney P. Sterben, Charitha C. Anamala, Sahan B. S. Kansakar, Vaishnavi Koduri, Volha Liaudanskaya   +4 more
wiley   +1 more source

Anti-mouse plexin A1 antibodies.

, 2016
Anti-mouse plexin A1 antibodies.
Kei Suzuki (341150), Atsushi Kumanogoh (50659), Ryusuke Omiya (2817769), Takeshi Baba (1313910), Kunihiro Hattori (384401), Junichi Takagi (3812), Sachiyo Suzuki (384398), Hiroyuki Tsunoda (410876), Hiroaki Segawa (2817766), Kenji Iwasaki (352584), Kyoko Matoba (2817772)   +10 more
core   +1 more source

Transmembrane recognition of the semaphorin co-receptors neuropilin 1 and plexin A1: coarse-grained simulations. [PDF]

PLoS ONE, 2014
The cancer associated class 3 semaphorins require direct binding to neuropilins and association to plexins to trigger cell signaling. Here, we address the role of the transmembrane domains of neuropilin 1 and plexin A1 for the dimerization of the two ...
Samia Aci-Sèche, Paul Sawma, Pierre Hubert, James N Sturgis, Dominique Bagnard, Laurent Jacob, Monique Genest, Norbert Garnier   +7 more
doaj   +1 more source