Results 51 to 60 of about 7,658 (197)

Dynamic regulation of semaphorin 7A and adhesion receptors in ovarian follicle remodeling and ovulation

Frontiers in Cell and Developmental Biology, 2023
The ovarian follicle is a complex structure that protects and helps in the maturation of the oocyte, and then releases it through the controlled molecular and structural remodeling process of ovulation.
Alaknanda Emery, Kylie R. Dunning, Doan T. Dinh, Lisa K. Akison, Rebecca L. Robker, Darryl L. Russell   +5 more
doaj   +1 more source

ADAM17 and its proteolytic targets in disease pathogenesis

The FEBS Journal, EarlyView.
ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

Rnd3-induced cell rounding requires interaction with Plexin-B2 [PDF]

, 2016
Rnd proteins are atypical members of the Rho GTPase family that induce actin cytoskeletal reorganization and cell rounding. Rnd proteins have been reported to bind to the intracellular domain of several plexin receptors, but whether plexins contribute to
Riou, Philippe, McColl, Brad, Ridley, Anne J, Garg, Ritu, Riento, Kirsi, Ridley, Anne J.   +5 more
core   +1 more source

Plexin B1 controls Treg numbers, limits allergic airway inflammation, and regulates mucins

Frontiers in Immunology
We investigated the effect of global Plexin B1 deficiency on allergic airway responses to house dust mite (HDM) or ovalbumin (OVA). In the HDM model, there were higher Th2 cytokine levels in the BALF of Plexin B1 knock-out (KO) mice compared to wild type
Svetlana P. Chapoval, Svetlana P. Chapoval, Svetlana P. Chapoval, Hongjuan Gao, Hongjuan Gao, Rachel Fanaroff, Achsah D. Keegan, Achsah D. Keegan, Achsah D. Keegan, Achsah D. Keegan   +9 more
doaj   +1 more source

Plexin B2 Is a Regulator of Monocyte Apoptotic Cell Disassembly

Cell Reports, 2019
Summary: Billions of cells undergo apoptosis daily and often fragment into small, membrane-bound extracellular vesicles termed apoptotic bodies (ApoBDs).
Georgia K. Atkin-Smith, Mark A. Miles, Rochelle Tixeira, Fung T. Lay, Mubing Duan, Christine J. Hawkins, Thanh Kha Phan, Stephanie Paone, Suresh Mathivanan, Mark D. Hulett, Weisan Chen, Ivan K.H. Poon   +11 more
doaj   +1 more source

Synchronizing the Osteochondral Regeneration Process through Spatial Patterning of Stable and Hypertrophic Cartilage Organoids

Advanced Materials, Volume 38, Issue 33, 12 June 2026.
Zonated osteochondral assembloid implants are engineered through scaffold‐free spatial assembly of induced pluripotent stem cell (iPSC)‐derived chondrocyte organoids and periosteum‐derived osteogenic organoids. Implanted into full‐thickness rat osteochondral defects, they promote hyaline‐like cartilage repair, support subchondral bone formation with ...
Liuqi Peng, Isaak Decoene, Hanna Svitina, Ioannis Papantoniou   +3 more
wiley   +1 more source

Different Requirement for Rnd GTPases of R-Ras GAP Activity of Plexin-C1 and Plexin-D1 [PDF]

Journal of Biological Chemistry, 2009
Plexins, comprising Plexin-A, -B, -C, and -D subfamilies, are receptors for semaphorins governing cell adhesion, migration, and axon guidance. Among plexin subfamilies, Plexin-A1 and Plexin-B1 have been shown to function as an R-Ras GAP, inducing repulsive responses, and the expression of R-Ras GAP activity requires the binding of Rnd1, a member of Rnd
Kanami, Uesugi, Izumi, Oinuma, Hironori, Katoh, Manabu, Negishi   +3 more
openaire   +2 more sources

Interactions between Plexin-A2, Plexin-A4, and Semaphorin 6A Control Lamina-Restricted Projection of Hippocampal Mossy Fibers

, 2007
SummaryHippocampal mossy fibers project preferentially to the stratum lucidum, the proximal-most lamina of the suprapyramidal region of CA3. The molecular mechanisms that govern this lamina-restricted projection are still unknown.
Tsuboi, Miu, Yagi, Takeshi, Shimizu, Masayuki, Komai, Shoji, Suto, Fumikazu, Mizuno, Hidenobu, Chédotal, Alain, Hiromi, Yasushi, Manabe, Toshiya, Fujisawa, Hajime, Kiyama, Yuji, Sanbo, Makoto, Mitchell, Kevin J., Kamiya, Haruyuki   +13 more
core   +1 more source

Dorsal turning of motor corticospinal axons at the pyramidal decussation requires plexin signaling

Neural Development, 2008
Background The development of the corticospinal tract (CST) in higher vertebrates relies on a series of axon guidance decisions along its long projection pathway.
Coble Jeffrey, Liu Xiao-Bo, Low Lawrence K, Faulkner Regina L, Jones Edward G, Cheng Hwai-Jong   +5 more
doaj   +1 more source