Results 51 to 60 of about 6,576 (169)

Dorsal turning of motor corticospinal axons at the pyramidal decussation requires plexin signaling

Neural Development, 2008
Background The development of the corticospinal tract (CST) in higher vertebrates relies on a series of axon guidance decisions along its long projection pathway.
Coble Jeffrey, Liu Xiao-Bo, Low Lawrence K, Faulkner Regina L, Jones Edward G, Cheng Hwai-Jong   +5 more
doaj   +1 more source

Periodontitis as a Model for Inflammatory Uncoupling of Bone Remodeling

Journal of Periodontal Research, EarlyView.
Periodontitis can be viewed as a state of inflammatory uncoupling of bone remodeling, in which excessive osteoclast‐mediated resorption coexists with impaired bone formation. This review integrates emerging insights from osteoimmunology, osteocyte biology, mechanobiology, aging, and resolution pathways to position periodontitis as an accessible in vivo
Rafael Scaf de Molon, Sotirios Tetradis, Rolando Vernal, Fabio Renato Manzolli Leite, Thomas E. Van Dyke   +4 more
wiley   +1 more source

Predicting Relevant Microglia‐Associated Cell–Cell Communication Pathways in Alzheimer's Disease: A Role for SPP1

Glia, Volume 74, Issue 10, October 2026.
We used CellChat to infer altered cell–cell communication in Alzheimer's disease Microglia signal to each other via SPP1 in Alzheimer's disease. SPP1‐expressing microglia are present around amyloid‐β plaques. ABSTRACT Microglia play a key role in the pathophysiology of Alzheimer's Disease (AD) and their increased heterogeneity likely affects disease ...
Janssen M. Kotah, Marina Trombetta Lima, Esmée C. Dragt, Asimenia Voulgaroglou, Nieske Brouwer, Inge R. Holtman, Susanne M. Kooistra, Bart J. L. Eggen   +7 more
wiley   +1 more source

Different Requirement for Rnd GTPases of R-Ras GAP Activity of Plexin-C1 and Plexin-D1 [PDF]

Journal of Biological Chemistry, 2009
Plexins, comprising Plexin-A, -B, -C, and -D subfamilies, are receptors for semaphorins governing cell adhesion, migration, and axon guidance. Among plexin subfamilies, Plexin-A1 and Plexin-B1 have been shown to function as an R-Ras GAP, inducing repulsive responses, and the expression of R-Ras GAP activity requires the binding of Rnd1, a member of Rnd
Kanami, Uesugi, Izumi, Oinuma, Hironori, Katoh, Manabu, Negishi   +3 more
openaire   +2 more sources

Integrative Multi‐Omics Analysis Reveals the Tumor‐Suppressive and Immunoregulatory Roles of SEMA5B in Prostate Cancer

BioFactors, Volume 52, Issue 4, July/August 2026.
This study identifies SEMA5B as a tumor suppressor in prostate cancer that suppresses the malignant phenotype, affects mitochondrial oxidative metabolism, induces cell cycle arrest and apoptosis, and is associated with the immune‐inflammatory tumor microenvironment, highlighting its potential as a biomarker and target for immunotherapy. ABSTRACT SEMA5B
Zhiguo Fan, Yihaoyun Lou, Xuan Zhou, Guang Liu, Xiaomin Zhang, Yuanjie Tang, Zhen Zhu, Shancheng Ren, Yifan Chang   +8 more
wiley   +1 more source

Patients With B3GALT6‐Linkeropathies Display Sialylated Disaccharides as Truncated Glycosaminoglycan Linkage Regions of Specific Core Proteins

Proteoglycan Research, Volume 4, Issue 3, July 2026.
ABSTRACT The Ehlers–Danlos syndromes (EDS) are a group of heritable connective tissue disorders, characterized by varying degrees of joint hypermobility, skin hyperextensibility and extracellular matrix defects. Spondylodysplastic type of EDS (spEDS) is a rare type of this group that can be caused by pathogenic variants in the B3GALT6 gene, coding for ...
Noborn Fredrik, Nilsson Jonas, Blomqvist Maria, Syx Delfien, Mendoza‐Londono Roberto, Malfait Fransiska, Larson Göran   +6 more
wiley   +1 more source

Serum Levels of Plexin B2 in Psoriasis: A case-control study

SVU - International Journal of Medical Sciences
Background: Psoriasis is a severe, long-lasting, immune-mediated, hyperproliferative, and inflammatory skin condition that can cause painful or itchy lesions and have a significant impact on quality of life.
Eisa M. Hegazy , Moustafa A El- Taieb , Mohammed Hassan , Ebtehal A El-Din , Hassan M. Ibrahim   +4 more
doaj   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, Volume 293, Issue 13, Page 3899-3953, July 2026.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

Plexin A3 and plexin A4 convey semaphorin signals during facial nerve development

Developmental Biology, 2008
In vertebrates, class 3 semaphorins (SEMA3) control axon behaviour by binding to neuronal cell surface receptors composed of a ligand binding subunit termed neuropilin (NRP) and a signal transduction subunit of the A-type plexin family (PLXNA). We have determined the requirement for SEMA3/NRP/PLXN signalling in the development of the facial nerve ...
Schwarz, Quenten, Waimey, Kathryn E., Golding, Matthew, Takamatsu, Hyota, Kumanogoh, Atsushi, Fujisawa, Hajime, Cheng, Hwai-Jong, Ruhrberg, Christiana   +7 more
openaire   +2 more sources

Plexin‐B3 is a functional receptor for semaphorin 5A [PDF]

The EMBO Reports, 2004
Semaphorins are a large family of molecular cues implicated in neural development and in a variety of functions outside the nervous system. Semaphorin 5A (Sema5A) is a transmembrane semaphorin, containing seven thrombospondin type-1 repeats, which was recently found to control axon guidance.
Artigiani, Stefania, Conrotto, Paolo, Fazzari, Pietro, Gilestro, Giorgio F., Barberis, Davide, Giordano, Silvia, Comoglio, Paolo M., Tamagnone, Luca   +7 more
openaire   +2 more sources