Results 71 to 80 of about 7,658 (197)
Advanced Science, Volume 13, Issue 29, 22 May 2026.Gastric cancer‐derived exosomal TAGLN2 is identified as a key mediator of vascular reprogramming, with significantly elevated levels detected in patient serum. Independent of canonical SEMA4D signaling, it nucleates a cytoplasmic TAGLN2/NRP1/SEMA4D ternary complex that dually activates YAP, promoting angiogenesis, vascular dysfunction, and metastasis ...
Shuqi Yu +7 more
wiley +1 more source
Identification and characterization of critical determinants in plexin signaling
, 2022 Semaphorins, a class of soluble and membrane-bound ligands, and their corresponding receptors, plexins, play a pivotal role in organogenesis, physiology of different tissues and organ systems, as well as in the development of diseases.
Höß, Carsten William
core +1 more source
Rap2 and TNIK control Plexin-dependent tiled synaptic innervation in C. elegans
eLife, 2018 During development, neurons form synapses with their fate-determined targets. While we begin to elucidate the mechanisms by which extracellular ligand-receptor interactions enhance synapse specificity by inhibiting synaptogenesis, our knowledge about ...
Xi Chen +8 more
doaj +1 more source
How does type 2 diabetes modify the risk of Alzheimer's disease?
Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.Abstract Type 2 diabetes (T2D) and Alzheimer's disease (AD) are both increasing exponentially worldwide. T2D has also been identified as one of 14 modifiable risk factors for dementia, but the mechanism is unknown. T2D could promote dementia via vascular or AD neuropathological changes, and mechanistic hypotheses include central insulin resistance and ...
G. T. Sutherland +7 more
wiley +1 more source
Sema4C-Plexin B2 signalling modulates ureteric branching in developing kidney
, 2011 Semaphorins, originally identified as axon guidance molecules, have also been implicated in angiogenesis, function of the immune system and cancerous growth.
Junia Y. Penachioni +19 more
core +2 more sources
Nature Communications, 2019 Semaphorin-plexin interactions regulate various developmental processes in Drosophila but the structural basis of these signaling events is unclear. Here, the authors present crystal structures of all Drosophila class 1 and 2 semaphorins, and elucidate ...
Daniel Rozbesky +7 more
doaj +1 more source
Evaluating Protein Enrichment Methods to Improve Biomarker Discovery in Equine Cerebrospinal Fluid
Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.Here, we compared two protein enrichment methods—ProteoMiner Small‐Capacity and PreOmics Enrich‐iST—for proteomic analysis of equine cerebrospinal fluid (CSF). PreOmics Enrich‐iST achieved superior depletion of high‐abundance proteins and identified a greater number of low‐abundance, neuropathology‐relevant proteins than ProteoMiner or native digestion.
Foti Federico +5 more
wiley +1 more source
The Activity of the Plexin-A1 Receptor Is Regulated by Rac [PDF]
Journal of Biological Chemistry, 2004 Plexins constitute a large family of transmembrane proteins that act as receptors for the semaphorin family of ligands. They are best known for their role in growth cone guidance, although they also are widely expressed outside the nervous system. Plexins are thought to control axon guidance by modifying the growth cone cytoskeleton, and Rho GTPases ...
Laura J, Turner +2 more
openaire +2 more sources
Plexin Signaling via Off-Track and Rho Family GTPases
, 2001 Two papers in this issue of Neuron examine new aspects of Semaphorin signaling via Plexin receptors. Winberg et al. present evidence that the transmembrane protein Off-track (OTK) interacts biochemically and genetically with Plexin A and is important for
Ghosh, Anirvan, Whitford, Kristin L
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Semaphorin signaling in vertebrate neural circuit assembly
Frontiers in Molecular Neuroscience, 2012 Neural circuit formation requires the coordination of many complex developmental processes. First, neurons project axons over long distances to find their final targets and then establish appropriate connectivity essential for the formation of neuronal ...
Yutaka eYoshida
doaj +1 more source