Results 91 to 100 of about 6,579 (168)
Semaphorin 3C and Its Receptors in Cancer and Cancer Stem-Like Cells
Biomedicines, 2018 Neurodevelopmental programs are frequently dysregulated in cancer. Semaphorins are a large family of guidance cues that direct neuronal network formation and are also implicated in cancer. Semaphorins have two kinds of receptors, neuropilins and plexins.
Jing Hao, Jennifer S. Yu
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eLife, 2014 Human SEMAPHORIN 5A (SEMA5A) is an autism susceptibility gene; however, its function in brain development is unknown. In this study, we show that mouse Sema5A negatively regulates synaptogenesis in early, developmentally born, hippocampal dentate granule
Yuntao Duan +6 more
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The Role of Semaphorin 4D in Bone Remodeling and Cancer Metastasis
Frontiers in Endocrinology, 2018 Semaphorin 4D (Sema4D; CD100) is a transmembrane homodimer 150-kDa glycoprotein member of the Semaphorin family. Semaphorins were first identified as chemorepellants that guide neural axon growth. Sema4D also possesses immune regulatory activity.
Konstantinos Lontos +5 more
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Optogenetic activation of Plexin-B1 reveals contact repulsion between osteoclasts and osteoblasts
Nature Communications, 2017 Osteoclasts induce chemotaxis of osteoblasts during bone remodelling, but maintain spatial segregation. Here the authors show that osteoclasts repel osteoblasts via contact inhibition of locomotion mediated by Semaphorin-Plexin signalling and develop an ...
Abhijit Deb Roy +5 more
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Plexin Activation Relies on an Array of Receptors
PLoS Biology, 2011 YoungYoung nerve cells put out cellular extensions called axons that must navigate through a maze of environmental cues in order to find their targets. Making the correct cellular connections is critical to building a functioning nervous system. In order to interpret these external cues, axons use receptor proteins that are directly embedded in the ...
openaire +4 more sources
Roles of Sema4D and Plexin-B1 in tumor progression
Molecular Cancer, 2010 Sema4D, also known as CD100, is a protein belonging to class IV semaphorin. Its physiologic roles in the immune and nervous systems have been extensively explored. However, the roles of Sema4D have extended beyond these traditionally studied territories.
Kumanogoh Atsushi, Ch'ng Ewe Seng
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Plexins function in epithelial repair in both Drosophila and zebrafish
Nature Communications, 2016 Plexins are semaphorin receptors and are well known for their roles in neuronal pathfinding. Here the authors describe a role for Plexin A in healing damaged epithelia in Drosophila and zebrafish. In Drosophila, Plexin A inhibits the GTPase Rap1 to allow
Sa Kan Yoo +6 more
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Endometrial expression of β3 integrin, calcitonin and plexin-B1 in the window of implantation in women with unexplained infertility [PDF]
International Journal of Reproductive BioMedicine, 2017 Background: Endometrial receptivity plays a key role in the establishment of successful implantation and its impairment may contribute to subfertility and limit the assisted reproduction techniques (ART) success.
Mehran Dorostghoal +3 more
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Directional guidance to orient Schwann cell alignment in nerve regeneration requires Plexin-B1. [PDF]
Sci AdvLi J +9 more
europepmc +1 more source