Results 91 to 100 of about 7,658 (197)
eLife, 2014 Human SEMAPHORIN 5A (SEMA5A) is an autism susceptibility gene; however, its function in brain development is unknown. In this study, we show that mouse Sema5A negatively regulates synaptogenesis in early, developmentally born, hippocampal dentate granule
Yuntao Duan +6 more
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Plexin Activation Relies on an Array of Receptors
PLoS Biology, 2011 YoungYoung nerve cells put out cellular extensions called axons that must navigate through a maze of environmental cues in order to find their targets. Making the correct cellular connections is critical to building a functioning nervous system. In order to interpret these external cues, axons use receptor proteins that are directly embedded in the ...
openaire +4 more sources
Optogenetic activation of Plexin-B1 reveals contact repulsion between osteoclasts and osteoblasts
Nature Communications, 2017 Osteoclasts induce chemotaxis of osteoblasts during bone remodelling, but maintain spatial segregation. Here the authors show that osteoclasts repel osteoblasts via contact inhibition of locomotion mediated by Semaphorin-Plexin signalling and develop an ...
Abhijit Deb Roy +5 more
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The Role of Semaphorin 4D in Bone Remodeling and Cancer Metastasis
Frontiers in Endocrinology, 2018 Semaphorin 4D (Sema4D; CD100) is a transmembrane homodimer 150-kDa glycoprotein member of the Semaphorin family. Semaphorins were first identified as chemorepellants that guide neural axon growth. Sema4D also possesses immune regulatory activity.
Konstantinos Lontos +5 more
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, 2010 Melanoma arises through complex genetic and epigenetic changes, resulting in uncontrolled proliferation, invasion, and metastatic disease. Semaphorins regulate axon guidance through interaction with their receptors, plexins and neuropilins.
Williamson, Magali +5 more
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Plexins function in epithelial repair in both Drosophila and zebrafish
Nature Communications, 2016 Plexins are semaphorin receptors and are well known for their roles in neuronal pathfinding. Here the authors describe a role for Plexin A in healing damaged epithelia in Drosophila and zebrafish. In Drosophila, Plexin A inhibits the GTPase Rap1 to allow
Sa Kan Yoo +6 more
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Roles of Sema4D and Plexin-B1 in tumor progression
Molecular Cancer, 2010 Sema4D, also known as CD100, is a protein belonging to class IV semaphorin. Its physiologic roles in the immune and nervous systems have been extensively explored. However, the roles of Sema4D have extended beyond these traditionally studied territories.
Kumanogoh Atsushi, Ch'ng Ewe Seng
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Plexin-B2 Controls the Development of Cerebellar Granule Cells
, 2007 Cerebellar granule cell progenitors proliferate postnatally in the upper part of the external granule cell layer (EGL) of the cerebellum. Postmitotic granule cells differentiate and migrate, tangentially in the EGL and then radially through the molecular
Tessier-Lavigne, Marc +13 more
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, 2009 The peripheral nervous system (PNS) of higher vertebrates is segmented to align the spinal nerve roots with the vertebrae. This co-patterning is set up during embryogenesis, when vertebrae develop from the sclerotome layer of the metameric somites, and ...
Maden, CH +11 more
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Signaling mechanisms of the semaphorin receptor plexin -B1.
, 2003 Semaphorins are chemorepulsive molecules that signal via plexin-containing receptor complexes to effect changes in the cytoskeleton required for growth cone turning or collapse.
Vikis, Haris G.
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