Results 81 to 90 of about 7,658 (197)

Architecture of the Sema3A/PlexinA4/Neuropilin tripartite complex

Nature Communications, 2021
Secreted class 3 semaphorins (Sema3s) form tripartite complexes with a plexin receptor and neuropilin co-receptor to transduce signals for neuronal axon guidance and other processes.
Defen Lu, Guijun Shang, Xiaojing He, Xiao-chen Bai, Xuewu Zhang   +4 more
doaj   +1 more source

What's Hot and What's New in Xenotransplantation From the Young Investigator Committee of the IXA–Basic and Translational Science

Xenotransplantation, Volume 33, Issue 3, May/June 2026.
ABSTRACT Xenotransplantation has been iteratively improved over the last decade in pre‐clinical models, with first‐in‐human clinical trials underway. The 2025 IXA Congress in Geneva was held in parallel with meetings involving World Health Organization leaders to support the development of new guidance on xenotransplantation in this rapidly evolving ...
Corbin E. Goerlich, Evelyn J. Salvaris, Konrad Fischer, Antonio Citro, Alessia Giarraputo, Joseph Ladowski, Emilien Seizilles de Mazancourt, Liaoran Wang, Daniel Eisenson, Margaret R. Connolly, Jeffrey Stern, Alban Longchamp, Raphael P. H. Meier   +12 more
wiley   +1 more source

Single‐cell transcriptomics reveals cellular heterogeneity and phenotypic transitions of smooth muscle cells in aortic dissection

iMeta, Volume 5, Issue 2, April 2026.
We utilized single‐cell RNA sequencing (scRNA‐seq) to investigate cellular heterogeneity and signaling networks in aortic dissection (AD) tissues compared to adjacent normal tissues. The analysis identified five smooth muscle cell (SMC) subtypes, with SMC2 linked to fibrosis and SMC3 associated with inflammation.
Liang Shao, Fan Hu, Ling‐Na Zhao, Jian‐Ping Luo, Peng‐Tao Zou, Xiu Liu, Shao‐Yi Zheng, Cong Chen, Lin‐Xiong Ye, Yu‐Xuan Zhou, Jiaqi Zhang, Kaidi Jin, Ping Zhang   +12 more
wiley   +1 more source

Pushing Frontiers for Proteoglycans

Proteoglycan Research, Volume 4, Issue 2, April 2026.
ABSTRACT Almost half of proteins have one or more post‐translational glycosylation modifications involving the addition of glycan structures. Proteoglycans are a class of glycosylated proteins with one or more glycosaminoglycan (GAG) chains covalently attached to the core protein.
Marissa L. Maciej‐Hulme
wiley   +1 more source

plexin-A4/plexin-D1 complexes convey semaphorin-3C signals to induce cytoskeletal collapse in the absence of neuropilins

, 2018
Class-3 semaphorin guidance factors bind to receptor complexes containing neuropilin and plexin receptors. A semaphorin may bind to several receptor complexes containing somewhat different constituents, resulting in diverse effects on cell migration ...
Ofra Kessler, Gera Neufeld, Tatyana Smolkin, Inbal Nir-Zvi, Yelena Mumblat, Nerri Duvshani   +5 more
core   +1 more source

Loss of plexin-B3 in hepatocellular carcinoma

Experimental and Therapeutic Medicine, 2015
Plexins are the primary receptors of semaphorins, and participate in the majority of intracellular pathways triggered by semaphorins, including the regulation of cell adhesion and the motility of numerous cell types. Recently, several studies have reported that plexins can significantly affect different aspects of cancer cell biology, and the aberrant ...
LIU, YUWU, WU, CHANG, WANG, YING, WEN, SAILAN, WANG, JUNPU, CHEN, ZHIHONG, HE, QIONGQIONG, FENG, DEYUN   +7 more
openaire   +3 more sources

Function and regulation of Rnd proteins in cortical projection neuron migration

Frontiers in Neuroscience, 2015
The mammalian cerebral cortex contains a high variety of neuronal subtypes that acquire precise spatial locations and form long or short-range connections to establish functional neuronal circuits.
Roberta eAzzarelli, Francois eGuillemot, Emilie ePacary, Emilie ePacary   +3 more
doaj   +1 more source

The role of the plexin-A2 receptor in semaphorin-3A and semaphorin-3B signal transduction. [PDF]

, 2014
Class-3 semaphorins are anti-angiogenic and anti-tumorigenic guidance factors that bind to neuropilins which in turn associate with class-A plexins to transduce semaphorin signals.
Sabag, A.D., Mumblat, Y., Kessler, O., Smolkin, T., Gloeckner, C.J., Neufeld, G., Ueffing, M.   +6 more
core   +1 more source

Plexin proteins predicted from the G. bimaculatus transcriptome share most of the functional domains found in Drosophila Plexin proteins.

, 2018
A) The type, number, and order of protein domains was assessed using Drosophila Plexin A, isoform A (AAF59394) and the putative G. bimaculatus Plexin A (TRINITY_DN159247_c0_g1_i2) as queries in a conserved domain search.
Micah G. Pascual (840888), Colby T. Joncas (5504309), Sylvia I. Jimenez (5504321), Hadley W. Horch (410110), David A. Michaelson (5504315), Harrison P. Fisher (5504312), Eleanor D. Quenzer (5504318), Andrew E. Christie (524405)   +7 more
core   +1 more source

Semaphorin 3C and Its Receptors in Cancer and Cancer Stem-Like Cells

Biomedicines, 2018
Neurodevelopmental programs are frequently dysregulated in cancer. Semaphorins are a large family of guidance cues that direct neuronal network formation and are also implicated in cancer. Semaphorins have two kinds of receptors, neuropilins and plexins.
Jing Hao, Jennifer S. Yu
doaj   +1 more source