Results 81 to 90 of about 6,579 (168)
Epigenetic Aging in Brain Tissue of the Self‐Fertilizing Vertebrate, Kryptolebias marmoratus
Ecology and Evolution, Volume 16, Issue 6, June 2026.Using the self‐fertilizing vertebrate Kryptolebias marmoratus, we developed an epigenetic clock from brain tissue that predicts chronological age with high accuracy, demonstrating that DNA methylation changes consistently with age even in the near absence of genetic variation. The 40 age‐associated CpG sites identified map to genes with conserved roles
Justine Bélik, Frédéric Silvestre
wiley +1 more source
Aspartame Increases the Risk of Pancreatic Ductal Adenocarcinoma
eFood, Volume 7, Issue 3, June 2026.Aspartame (APM) is a widely used artificial sweetener associated with various health concerns, including potential links to diabetes, cardiovascular diseases, and an increased risk of cancer. A comprehensive approach incorporating data mining, machine learning, network toxicology, molecular docking, molecular dynamics simulations, and clinical sample ...
Jumin Xie +5 more
wiley +1 more source
Plexin-B2, But Not Plexin-B1, Critically Modulates Neuronal Migration and Patterning of the Developing Nervous System In Vivo [PDF]
Journal of Neuroscience, 2007 Semaphorins and their receptors, plexins, have emerged as important cellular cues regulating key developmental processes. B-type plexins directly regulate the actin cytoskeleton in a variety of cell types. Recently, B-type plexins have been shown to be expressed in striking patterns in the nervous system over critical developmental windows. However, in
Deng, S +11 more
openaire +3 more sources
Function and regulation of Rnd proteins in cortical projection neuron migration
Frontiers in Neuroscience, 2015 The mammalian cerebral cortex contains a high variety of neuronal subtypes that acquire precise spatial locations and form long or short-range connections to establish functional neuronal circuits.
Roberta eAzzarelli +3 more
doaj +1 more source
c‐Met‐Targeted Imaging Agents: Progress and Challenges
iRADIOLOGY, Volume 4, Issue 3, Page 219-245, June 2026.This review summarizes recent advances in c‐Met‐targeted imaging probes, including hepatocyte growth factor (HGF) ligands, antibodies, peptides, and small molecules across magnetic resonance imaging (MRI), positron emission tomography (PET), single‐photon emission computed tomography (SPECT), and optical imaging modalities.
Yonghao Li +4 more
wiley +1 more source
Rap2 and TNIK control Plexin-dependent tiled synaptic innervation in C. elegans
eLife, 2018 During development, neurons form synapses with their fate-determined targets. While we begin to elucidate the mechanisms by which extracellular ligand-receptor interactions enhance synapse specificity by inhibiting synaptogenesis, our knowledge about ...
Xi Chen +8 more
doaj +1 more source
Neuroprotection, Volume 4, Issue 2, Page 131-142, June 2026.The critical transition from amyloid pathology to irreversible neuronal loss in Alzheimer's disease hinges on the microglial response. This review aims to systematize the patterns of how microglia react within the glial context. Abstract Microglia mount coordinated, stage‐dependent compensatory programs in response to early amyloid β (Aβ) accumulation ...
Songtao Lei +3 more
wiley +1 more source
Semaphorin signaling in vertebrate neural circuit assembly
Frontiers in Molecular Neuroscience, 2012 Neural circuit formation requires the coordination of many complex developmental processes. First, neurons project axons over long distances to find their final targets and then establish appropriate connectivity essential for the formation of neuronal ...
Yutaka eYoshida
doaj +1 more source
Biochemical bone biomarkers in plasma cell dyscrasias
British Journal of Haematology, Volume 208, Issue 6, Page 1909-1923, June 2026.Visual abstract depicting that bone turnover markers reflect dynamic alterations in bone remodelling across the spectrum of plasma cell dyscrasias but remain limited by assay variability, biological confounding and incomplete integration with imaging and risk stratification.
Guido Nador +4 more
wiley +1 more source
Loss of plexin-B3 in hepatocellular carcinoma
Experimental and Therapeutic Medicine, 2015 Plexins are the primary receptors of semaphorins, and participate in the majority of intracellular pathways triggered by semaphorins, including the regulation of cell adhesion and the motility of numerous cell types. Recently, several studies have reported that plexins can significantly affect different aspects of cancer cell biology, and the aberrant ...
LIU, YUWU +7 more
openaire +3 more sources