Isoforms of Neuropilin-2 Denote Unique Tumor-Associated Macrophages in Breast Cancer
Frontiers in Immunology, 2022 Tumor-associated macrophages (TAMs) exert profound influence over breast cancer progression, promoting immunosuppression, angiogenesis, and metastasis. Neuropilin-2 (NRP2), consisting of the NRP2a and NRP2b isoforms, is a co-receptor for heparin-binding ...
Adrian Lee +2 more
exaly +3 more sources
Neuropilin 1 Regulation of Vascular Permeability Signaling
Biomolecules, 2021 The vascular endothelium acts as a selective barrier to regulate macromolecule exchange between the blood and tissues. However, the integrity of the endothelium barrier is compromised in an array of pathological settings, including ischemic disease and ...
Alessandro Fantin, Fantin Alessandro
exaly +3 more sources
Differential expression of viral entry protein neuropilin 1 (NRP1) and neuropilin 2 (NRP2) in fatal COVID-19 [PDF]
Journal of VirologyCoronavirus disease 2019 (COVID-19) is associated with hyperinflammation, endothelialitis, hypoxemia, and hypercoagulation, contributing to thrombosis in acute severe and long COVID. While ACE2 is the primary severe acute respiratory syndrome coronavirus
A. Dette +11 more
doaj +2 more sources
Development of Tumor Microenvironment-Responsive Nanoparticles with Enhanced Tissue Penetration [PDF]
NanomaterialsLiposomes modified with slightly acidic pH-sensitive peptides (SAPSp-lipo) are effectively delivered to tumor tissues, followed by cellular uptake in the tumor microenvironment.
Karin Kitamura +6 more
doaj +2 more sources
The Significance of Neuropilins in Gastrointestinal Cancers. [PDF]
Int J Mol SciCancers represent a significant global health concern, being among the most prevalent malignancies and contributing substantially to morbidity and mortality rates. Notably, colorectal, gastric, pancreatic, and liver cancers are the most frequently diagnosed among these malignancies.
Królikowska K +5 more
europepmc +4 more sources
Neuropilin-1 in Transplantation Tolerance [PDF]
Frontiers in Immunology, 2013 In the immune system, Neuropilin-1 (Nrp1) is a molecule that plays an important role in establishing the immunological synapse between dendritic cells (DCs) and T cells.
Mauricio eCampos-Mora +4 more
doaj +4 more sources
VEGFA, B, C: Implications of the C-Terminal Sequence Variations for the Interaction with Neuropilins
Biomolecules, 2022 Vascular endothelial growth factors (VEGFs) are the key regulators of blood and lymphatic vessels’ formation and function. Each of the proteins from the homologous family VEGFA, VEGFB, VEGFC and VEGFD employs a core cysteine-knot structural domain for ...
Charles Eldrid +7 more
doaj +1 more source
Neuropilin-2 expression promotes TGF-β1-mediated epithelial to mesenchymal transition in colorectal cancer cells. [PDF]
PLoS ONE, 2011 Neuropilins, initially characterized as neuronal receptors, act as co-receptors for cancer related growth factors and were recently involved in several signaling pathways leading to cytoskeletal organization, angiogenesis and cancer progression. Then, we
Camille Grandclement +12 more
doaj +1 more source
Expression and clinical significance of neuropilin-2 in colorectal cancer: correlation with lymphangiogenic factors [PDF]
Korean Journal of Clinical Oncology, 2013 Purpose: Neuropilin-2 is expressed by venous and lymphatic endothelial cells and can bind the lymphangiogenesis-associated ligand vascular endothelial growth factor (VEGF)-C and D.
Hyunyong Lee +5 more
doaj +1 more source
Targeting neuropilin-1 to inhibit VEGF signaling in cancer: Comparison of therapeutic approaches. [PDF]
PLoS Computational Biology, 2006 Angiogenesis (neovascularization) plays a crucial role in a variety of physiological and pathological conditions including cancer, cardiovascular disease, and wound healing.
Feilim Mac Gabhann, Aleksander S Popel
doaj +1 more source