Differential expression of viral entry protein neuropilin 1 (NRP1) and neuropilin 2 (NRP2) in fatal COVID-19 [PDF]
Journal of VirologyCoronavirus disease 2019 (COVID-19) is associated with hyperinflammation, endothelialitis, hypoxemia, and hypercoagulation, contributing to thrombosis in acute severe and long COVID. While ACE2 is the primary severe acute respiratory syndrome coronavirus
A. Dette +11 more
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Development of Tumor Microenvironment-Responsive Nanoparticles with Enhanced Tissue Penetration [PDF]
NanomaterialsLiposomes modified with slightly acidic pH-sensitive peptides (SAPSp-lipo) are effectively delivered to tumor tissues, followed by cellular uptake in the tumor microenvironment.
Karin Kitamura +6 more
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VEGFA, B, C: Implications of the C-Terminal Sequence Variations for the Interaction with Neuropilins
Biomolecules, 2022 Vascular endothelial growth factors (VEGFs) are the key regulators of blood and lymphatic vessels’ formation and function. Each of the proteins from the homologous family VEGFA, VEGFB, VEGFC and VEGFD employs a core cysteine-knot structural domain for ...
Charles Eldrid +7 more
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Neuropilin-2 expression promotes TGF-β1-mediated epithelial to mesenchymal transition in colorectal cancer cells. [PDF]
PLoS ONE, 2011 Neuropilins, initially characterized as neuronal receptors, act as co-receptors for cancer related growth factors and were recently involved in several signaling pathways leading to cytoskeletal organization, angiogenesis and cancer progression. Then, we
Camille Grandclement +12 more
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Expression and clinical significance of neuropilin-2 in colorectal cancer: correlation with lymphangiogenic factors [PDF]
Korean Journal of Clinical Oncology, 2013 Purpose: Neuropilin-2 is expressed by venous and lymphatic endothelial cells and can bind the lymphangiogenesis-associated ligand vascular endothelial growth factor (VEGF)-C and D.
Hyunyong Lee +5 more
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Frontiers in Immunology, 2021 Semaphorins are a group of proteins that have been studied extensively for their critical function in neuronal development. They have been shown to regulate airway development, tumorigenesis, autoimmune diseases, and the adaptive immune response. Notably,
Shreya M. Kanth +2 more
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Targeting neuropilin-1 to inhibit VEGF signaling in cancer: Comparison of therapeutic approaches. [PDF]
PLoS Computational Biology, 2006 Angiogenesis (neovascularization) plays a crucial role in a variety of physiological and pathological conditions including cancer, cardiovascular disease, and wound healing.
Feilim Mac Gabhann, Aleksander S Popel
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Isoforms of Neuropilin-2 Denote Unique Tumor-Associated Macrophages in Breast Cancer
Frontiers in Immunology, 2022 Tumor-associated macrophages (TAMs) exert profound influence over breast cancer progression, promoting immunosuppression, angiogenesis, and metastasis. Neuropilin-2 (NRP2), consisting of the NRP2a and NRP2b isoforms, is a co-receptor for heparin-binding ...
Rajeev Dhupar +35 more
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Hepatology, EarlyView., 2022 Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid +20 more
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Neuropilin-2 Is Associated With Increased Hepatoblastoma Cell Viability and Motility
Frontiers in Pediatrics, 2021 The neuropilins NRP1 and NRP2 are multifunctional glycoproteins that have been implicated in several cancer-related processes including cell survival, migration, and invasion in various tumor types.
Katja Eloranta +9 more
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