Results 21 to 30 of about 17,164 (224)

Endothelial VEGFR Coreceptors Neuropilin-1 and Neuropilin-2 Are Essential for Tumor Angiogenesis [PDF]

Cancer Research Communications, 2022
Neuropilin (NRP) expression is highly correlated with poor outcome in multiple cancer subtypes. As known coreceptors for VEGFRs, core drivers of angiogenesis, past investigations have alluded to their functional roles in facilitating tumorigenesis by promoting invasive vessel growth. Despite this, it remains unclear as to whether NRP1 and NRP2 act in a
Christopher J. Benwell, Robert T. Johnson, James A.G.E. Taylor, Christopher A. Price, Stephen D. Robinson   +4 more
openaire   +3 more sources

Neuropilin 1 and 2 control cranial gangliogenesis and axon guidance through neural crest cells [PDF]

, 2008
Neuropilin (NRP) receptors and their class 3 semaphorin (SEMA3) ligands play well-established roles in axon guidance, with loss of NRP1, NRP2, SEMA3A or SEMA3F causing defasciculation and errors in growth cone guidance of peripherally projecting nerves ...
Howard, Beatrice, Christiana Ruhrberg, Quenten Schwarz, Britta J. Eickholt, Beatrice Howard, Vieira, J., Vieira, Joaquim M.; id_orcid, Ruhrberg, C., Howard, B, Ruhrberg, Christiana, Vieira, JM, Schwarz, Quenten, Joaquim M. Vieira, Eickholt, BJ, Schwarz, Q, Eickholt, Britta J., Howard, B., Eickholt, B., Ruhrberg, C, Schwarz, Q.P.   +19 more
core   +1 more source

Neuropilin-1/GIPC1 signaling regulates α5β1 integrin traffic and function in endothelial cells [PDF]

, 2009
Neuropilin 1 (Nrp1) is a coreceptor for vascular endothelial growth factor A165 (VEGF-A165, VEGF-A164 in mice) and semaphorin 3A (SEMA3A). Nevertheless, <i>Nrp1</i> null embryos display vascular defects that differ from those of mice lacking ...
Caccavari, Francesca, Valdembri, D., Serini, G., Valdembri, Donatella, Caccavari, F., Caswell Patrick T, Anderson, K.I., Humphries, M.J., Patrick T Caswell, Anderson Kurt I, Anderson, Kurt I., Serini, Guido, Caccavari Francesca, Federico Bussolino, Elena Astanina, Valdembri Donatella, König, I., König, Ireen, Astanina, Elena, Schwarz, J.P., Francesca Caccavari, Jim C Norman, Humphries Martin J, Bussolino, F., Schwarz Juliane P, Guido Serini, Serini Guido, König Ireen, Schwarz, Juliane P., Bussolino, Federico, Kurt I Anderson, Humphries, Martin J., Caswell, Patrick T.; id_orcid, Norman, Jim C., Juliane P Schwarz, Astanina Elena, Astanina, E., Bussolino Federico, Norman, J.C., Donatella Valdembri, Caswell, P.T., Ireen König, Norman Jim C, Martin J Humphries   +43 more
core   +1 more source

Semaphorin signaling in vertebrate neural circuit assembly

Frontiers in Molecular Neuroscience, 2012
Neural circuit formation requires the coordination of many complex developmental processes. First, neurons project axons over long distances to find their final targets and then establish appropriate connectivity essential for the formation of neuronal ...
Yutaka eYoshida
doaj   +1 more source

Architecture of the Sema3A/PlexinA4/Neuropilin tripartite complex

Nature Communications, 2021
Secreted class 3 semaphorins (Sema3s) form tripartite complexes with a plexin receptor and neuropilin co-receptor to transduce signals for neuronal axon guidance and other processes.
Defen Lu, Guijun Shang, Xiaojing He, Xiao-chen Bai, Xuewu Zhang   +4 more
doaj   +1 more source

In Silico and In Vivo Studies of a Tumor-Penetrating and Interfering Peptide with Antitumoral Effect on Xenograft Models of Breast Cancer

Pharmaceutics, 2023
The combination of a tumor-penetrating peptide (TPP) with a peptide able to interfere with a given protein–protein interaction (IP) is a promising strategy with potential clinical application.
Gustavo H. Marin, Samuel Murail, Laura Andrini, Marcela Garcia, Severine Loisel, Pierre Tuffery, Angelita Rebollo   +6 more
doaj   +1 more source

Semaphorin SEMA3F and VEGF Have Opposing Effects on Cell Attachment and Spreading

Neoplasia: An International Journal for Oncology Research, 2003
SEMA3F, isolated from a 3p21.3 deletion, has antitumor activity in transfected cells, and protein expression correlates with tumor stage and histology. In primary tumors, SEMA3F and VEGF surface staining is inversely correlated.
Patrick Nasarre, Bruno Constantin, Lydie Rouhaud, Thomas Harnois, Guy Raymond, Harry A. Drabkin, Nicolas Bourmeyster, Joëlle Roche   +7 more
doaj   +1 more source

The Pro-Tumoral Activity of Heparan Sulfate 3-O-Sulfotransferase 3B (HS3ST3B) in Breast Cancer MDA-MB-231 Cells Is Dependent on the Expression of Neuropilin-1

Molecules, 2018
Heparan sulfate 3-O-sulfotransferases (HS3STs) catalyze the maturation step of heparan sulfate (HS) 3-O-sulfation. This modification is relatively rare.
Charles Hellec, Mariama Diawara, Mathieu Carpentier, Agnès Denys, Fabrice Allain   +4 more
doaj   +1 more source

Role of Neuropilin-1/Semaphorin-3A signaling in the functional and morphological integrity of the cochlea. [PDF]

PLoS Genetics, 2017
Neuropilin-1 (Nrp1) encodes the transmembrane cellular receptor neuropilin-1, which is associated with cardiovascular and neuronal development and was within the peak SNP interval on chromosome 8 in our prior GWAS study on age-related hearing loss (ARHL)
Pezhman Salehi, Marshall X Ge, Usha Gundimeda, Leah Michelle Baum, Homero Lael Cantu, Joel Lavinsky, Litao Tao, Anthony Myint, Charlene Cruz, Juemei Wang, Angeliki Maria Nikolakopoulou, Carolina Abdala, Matthew William Kelley, Takahiro Ohyama, Thomas Matthew Coate, Rick A Friedman   +15 more
doaj   +1 more source

Semaphorin 3C and Its Receptors in Cancer and Cancer Stem-Like Cells

Biomedicines, 2018
Neurodevelopmental programs are frequently dysregulated in cancer. Semaphorins are a large family of guidance cues that direct neuronal network formation and are also implicated in cancer. Semaphorins have two kinds of receptors, neuropilins and plexins.
Jing Hao, Jennifer S. Yu
doaj   +1 more source