Results 41 to 50 of about 17,164 (224)
, 2009 The peripheral nervous system (PNS) of higher vertebrates is segmented to align the spinal nerve roots with the vertebrae. This co-patterning is set up during embryogenesis, when vertebrae develop from the sclerotome layer of the metameric somites, and ...
Maden, CH +11 more
core +1 more source
Targeting neuropilin-1 to inhibit prostate cancer invasion and metastasis
, 2015 Recent reports provide evidence\ud that the epithelial-to-mesenchymal\ud transition (EMT) plays a key role in prostate\ud cancer (PCa) metastasis and therapy\ud resistance.
McGowan, Kayla +14 more
core +2 more sources
Control of cellular motility by neuropilin-mediated physical interactions
Biomolecular Concepts, 2014 The neuropilin (Nrp) family consists of multifunctional cell surface receptors with critical roles in a number of different cell and tissue types. A core aspect of Nrp function is in ligand-dependent cellular migration, where it controls the multistep ...
Li Xiaobo +2 more
doaj +1 more source
Neuropilin-1 and Integrins as Receptors for Chromogranin A-Derived Peptides
Pharmaceutics, 2022 Human chromogranin A (CgA), a 439 residue-long member of the “granin” secretory protein family, is the precursor of several peptides and polypeptides involved in the regulation of the innate immunity, cardiovascular system, metabolism, angiogenesis ...
Angelo Corti +2 more
doaj +1 more source
Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function
Advanced Science, EarlyView.This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang +10 more
wiley +1 more source
Advanced Science, EarlyView.A supramolecular nanocomplex based on phenolic‐modified silk sericin is developed to deliver antioxidant enzymes across the blood–brain barrier and escape lysosomal degradation. This dual‐barrier‐crossing system reduces neuroinflammation and improves cognitive performance in Alzheimer's disease mouse model, offering a promising strategy for protein ...
Doudou Hu +5 more
wiley +1 more source
Neuropilin-1 Regulates the Secondary CD8 T Cell Response to Virus Infection
mSphere, 2019 Neuropilin-1 (Nrp1) plays important roles in axonal guidance in neurons and in the growth of new blood vessels. There is also a growing appreciation for roles played by neuropilin-1 in the immune response.
Ji Young Hwang +3 more
doaj +1 more source
Advanced Science, EarlyView.Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim +2 more
wiley +1 more source
Neuropilins in the Context of Tumor Vasculature [PDF]
International Journal of Molecular Sciences, 2019 Neuropilin-1 and Neuropilin-2 form a small family of plasma membrane spanning receptors originally identified by the binding of semaphorin and vascular endothelial growth factor. Having no cytosolic protein kinase domain, they function predominantly as co-receptors of other receptors for various ligands.
Stephan Niland, Johannes A. Eble
openaire +2 more sources
Transmembrane recognition of the semaphorin co-receptors neuropilin 1 and plexin A1: coarse-grained simulations. [PDF]
PLoS ONE, 2014 The cancer associated class 3 semaphorins require direct binding to neuropilins and association to plexins to trigger cell signaling. Here, we address the role of the transmembrane domains of neuropilin 1 and plexin A1 for the dimerization of the two ...
Samia Aci-Sèche +7 more
doaj +1 more source