Results 61 to 70 of about 17,164 (224)

Neuropilin-2, a Novel Member of the Neuropilin Family, Is a High Affinity Receptor for the Semaphorins Sema E and Sema IV but Not Sema III

, 1997
Semaphorins are a large family of secreted and transmembrane proteins, several of which are implicated in repulsive axon guidance. Neuropilin (neuropilin-1) was recently identified as a receptor for Collapsin-1/Semaphorin III/D (Sema III).
Chen, Hang, Tessier-Lavigne, Marc, He, Zhigang, Goodman, Corey S, Chédotal, Alain   +4 more
core   +1 more source

Neuropilin 1 and Neuropilin 2 gene invalidation or pharmacological inhibition reveals their relevance for the treatment of metastatic renal cell carcinoma

Journal of Experimental & Clinical Cancer Research, 2021
Background Despite the improvement of relapse-free survival mediated by anti-angiogenic drugs like sunitinib (Sutent®), or by combinations of anti-angiogenic drugs with immunotherapy, metastatic clear cell Renal Cell Carcinoma (mccRCC) remain incurable ...
Aurore Dumond, Etienne Brachet, Jérôme Durivault, Valérie Vial, Anna K. Puszko, Yves Lepelletier, Christopher Montemagno, Marina Pagnuzzi-Boncompagni, Olivier Hermine, Christiane Garbay, Nathalie Lagarde, Matthieu Montes, Luc Demange, Renaud Grépin, Gilles Pagès   +14 more
doaj   +1 more source

Mixed lineage kinase 3 mediates SARS‐CoV‐2‐induced kidney injury via the Hsp70‐IL‐17A axis

Interdisciplinary Medicine, EarlyView.
Kidney samples from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) showed upregulated expression and activity of Mixed Lineage Kinase (MLK3). Based on the mechanistic studies, we identified MLK3 as a critical player in promoting SARS‐CoV‐2‐induced kidney injury.
Sandeep Kumar, Sunil Kumar Singh, Piush Srivastava, Sowdhamini Mahendiran, Rakesh Sathish Nair, Harsh Vyas, Saket Jha, Niraj Nag, Navin Viswakarma, Hitesh Kapoor, Swathi Suresh, Periannan Sethupathi, Sang‐Ging Ong, Jerrold S. Levine, Suman Setty, Mathayan Manikannan, Bellur S. Prabhakar, Basabi Rana, Ajay Rana   +18 more
wiley   +1 more source

Neuropilin-1 is upregulated in the adaptive response of prostate tumors to androgen-targeted therapies and is prognostic of metastatic progression and patient mortality

, 2017
Neuropilin-1 is upregulated in the adaptive response of prostate tumors to androgen-targeted therapies and is prognostic of metastatic progression and patient ...
CC Nelson (15837548), PA Gregory (9884105), ML Lehman (15837554), BWC Tse (21766265), N Stylianou (17225392), L Fazli (16151672), ME Gleave (16151678), M Alshalafa (21794423), M Nouri (16307301), LA Selth (9884249), BG Hollier (21767279), PJ Russell (21690305), M Roshan-Moniri (21794411), J McGovern (13508143), ED Williams (9893567), N Erho (21794420), EM Schaeffer (21794426), MS Butler (15858779), J Caradec (21794414), JH Gunter (21782885), CY Gregory-Evans (15968843), M Takhar (21794417), R Buttyan (21782879), E Davicioni (16218146), E Ratther (21767276), K McGowan (7613696), SJ McPherson (21794408), PS Rennie (21794429), RB Den (21782936), AE Ross (21782933), R Das (12148338), RJ Karnes (16218143), M Volpert (21794405), RB Jenkins (16174535)   +33 more
core   +1 more source

Semaphorin SEMA3F Has a Repulsing Activity on Breast Cancer Cells and Inhibits E-Cadherin-Mediated Cell Adhesion

Neoplasia: An International Journal for Oncology Research, 2005
Previously, we demonstrated that loss of SEMA3F, a secreted semaphorin encoded in 3p21.3, is associated with higher stages in lung cancer and primary tumor cells studied with anti-vascular endothelial growth factor (VEGF) and SEMA3F antibodies. In vitro,
Patrick Nasarre, Sophie Kusy, Bruno Constantin, Valérie Castellani, Harry A. Drabkin, Dominique Bagnard, Joëlle Roche   +6 more
doaj   +1 more source

Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity

VIEW, EarlyView.
Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin, Galyna Bila, Ileana Manduteanu, Rostyslav Bilyy   +3 more
wiley   +1 more source

New perspectives on VEGF signalling in Alzheimer's disease

Brain Pathology, EarlyView.
Emery et al. bring together findings from recent multi‐omic studies, including single‐cell mRNA analysis of human post‐mortem brain tissue, and proteomic analysis of matched CSF and blood samples in large clinical studies. The authors present evidence of the involvement of altered VEGF signalling in vascular and immune dysfunction and neurodegeneration
Cherelle E. G. Emery, Seth Love, J. Scott Miners   +2 more
wiley   +1 more source

Neuropilins: expression and roles in the epithelium

International Journal of Experimental Pathology, 2012
SummaryInitially found expressed in neuronal and then later in endothelial cells, it is well established that the transmembrane glycoproteins neuropilin‐1 (NRP1) and neuropilin‐2 (NRP2) play essential roles in axonal growth and guidance and in physiological and pathological angiogenesis.
Jonathan R L, Wild, Carolyn A, Staton, Keith, Chapple, Bernard M, Corfe   +3 more
openaire   +3 more sources

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Semaphorin–Neuropilin Interactions Underlying Sympathetic Axon Responses to Class III Semaphorins

, 1998
Neuropilin-1 and neuropilin-2 show specificity in binding to different class III semaphorins, including Sema III, Sema E, and Sema IV, suggesting that the specificity of action of these semaphorins is dictated by the complement of neuropilins expressed ...
Chen, Hang, Tessier-Lavigne, Marc, He, Zhigang, Bagri, Anil   +3 more
core   +1 more source